Ageing-Associated Genes in Model Organisms
Found 136 results. Showing results 1 to 136.
Entrez ID | Symbol | Name | Organism | Longevity influence | Max average lifespan change | More details |
---|---|---|---|---|---|---|
224129 | Adcy5 | adenylate cyclase 5 | Mus musculus | Anti-Longevity |
30% ![]() |
Adcy5 |
11549 | Adra1a | adrenergic receptor, alpha 1a | Mus musculus | Pro-Longevity |
10% ![]() |
Adra1a |
11548 | Adra1b | adrenergic receptor, alpha 1b | Mus musculus | Anti-Longevity |
11% ![]() |
Adra1b |
11607 | Agtr1a | Angiotensin II receptor, type 1a | Mus musculus | Anti-Longevity |
26% ![]() |
Agtr1a |
11651 | Akt1 | thymoma viral proto-oncogene 1 | Mus musculus | Anti-Longevity |
12% ![]() |
Akt1 |
11652 | Akt2 | thymoma viral proto-oncogene 2 | Mus musculus | Anti-Longevity |
9% ![]() |
Akt2 |
11816 | Apoe | Apolipoprotein E | Mus musculus | Pro-Longevity |
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Apoe |
228359 | Arhgap1 | Rho GTPase activating protein 1 | Mus musculus | Pro-Longevity |
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Arhgap1 |
11865 | Arntl | aryl hydrocarbon receptor nuclear translocator-like | Mus musculus | Pro-Longevity |
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Arntl |
11793 | Atg5 | autophagy related 5 | Mus musculus | Pro-Longevity |
17% ![]() |
Atg5 |
11920 | Atm | Ataxia telangiectasia mutated homolog (human) | Mus musculus | Pro-Longevity |
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Atm |
245000 | Atr | Ataxia telangiectasia and Rad3 related | Mus musculus | Pro-Longevity |
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Atr |
12028 | Bax | Bcl2-associated X protein | Mus musculus | Unannotated |
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Bax |
12189 | Brca1 | Breast cancer 1 | Mus musculus | Pro-Longevity |
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Brca1 |
12236 | Bub1b | budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) | Mus musculus | Pro-Longevity |
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Bub1b |
12237 | Bub3 | budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae) | Mus musculus | Pro-Longevity |
12% ![]() |
Bub3 |
12366 | Casp2 | caspase 2 | Mus musculus | Pro-Longevity |
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Casp2 |
12359 | Cat | Catalase | Mus musculus | Pro-Longevity |
21% ![]() |
Cat |
12389 | Cav1 | caveolin, caveolae protein 1 | Mus musculus | Pro-Longevity |
50% ![]() |
Cav1 |
218294 | Cdc14b | CDC14 cell division cycle 14B | Mus musculus | Pro-Longevity | Cdc14b | |
12572 | Cdk7 | cyclin-dependent kinase 7 | Mus musculus | Pro-Longevity |
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Cdk7 |
12575 | Cdkn1a | Cyclin-dependent kinase inhibitor 1A | Mus musculus | Anti-Longevity |
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Cdkn1a |
12606 | Cebpa | CCAAT/enhancer binding protein (C/EBP), alpha | Mus musculus | Unannotated |
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Cebpa |
12608 | Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | Mus musculus | Unannotated |
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Cebpb |
50883 | Chek2 | CHK2 checkpoint homolog (S. pombe) | Mus musculus | Pro-Longevity |
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Chek2 |
67006 | Cisd2 | CDGSH iron sulfur domain 2 | Mus musculus | Pro-Longevity |
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Cisd2 |
12753 | Clock | Circadian locomotor output cycles kaput | Mus musculus | Pro-Longevity |
15% ![]() |
Clock |
12842 | Col1a1 | collagen, type I, alpha 1 | Mus musculus | Pro-Longevity |
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Col1a1 |
12850 | Coq7 | demethyl-Q 7 | Mus musculus | Anti-Longevity |
30% ![]() |
Coq7 |
13019 | Ctf1 | cardiotrophin 1 | Mus musculus | Anti-Longevity |
18% ![]() |
Ctf1 |
13350 | Dgat1 | diacylglycerol O-acyltransferase 1 | Mus musculus | Anti-Longevity |
23% ![]() |
Dgat1 |
13405 | Dmd | Dystrophin, muscular dystrophy | Mus musculus | Pro-Longevity |
18% ![]() |
Dmd |
66143 | Eef1e1 | Eukaryotic translation elongation factor 1 epsilon 1 | Mus musculus | Anti-Longevity |
50% ![]() |
Eef1e1 |
216616 | Efemp1 | Epidermal growth factor-containing fibulin-like extracellular matrix protein 1 | Mus musculus | Pro-Longevity |
20% ![]() |
Efemp1 |
208691 | Eif5a2 | eukaryotic translation initiation factor 5A2 | Mus musculus | Anti-Longevity |
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Eif5a2 |
13860 | Eps8 | Epidermal growth factor receptor pathway substrate 8 | Mus musculus | Anti-Longevity |
37% ![]() |
Eps8 |
13870 | Ercc1 | excision repair cross-complementing rodent repair deficiency, complementation group 1 | Mus musculus | Pro-Longevity |
83% ![]() |
Ercc1 |
13871 | Ercc2 | Excision repair cross-complementing rodent repair deficiency, complementation group 2 | Mus musculus | Pro-Longevity |
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Ercc2 |
50505 | Ercc4 | Excision repair cross-complementing rodent repair deficiency, complementation group 4 | Mus musculus | Pro-Longevity |
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Ercc4 |
56636 | Fgf21 | fibroblast growth factor 21 | Mus musculus | Pro-Longevity |
36% ![]() |
Fgf21 |
64654 | Fgf23 | Fibroblast growth factor 23 | Mus musculus | Pro-Longevity |
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Fgf23 |
14268 | Fn1 | Fibronectin 1 | Mus musculus | Pro-Longevity |
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Fn1 |
14235 | Foxm1 | Forkhead box M1 | Mus musculus | Pro-Longevity |
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Foxm1 |
14297 | Fxn | frataxin | Mus musculus | Pro-Longevity |
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Fxn |
2539 | G6PD | glucose-6-phosphate dehydrogenase | Mus musculus | Pro-Longevity |
14% ![]() |
G6PD |
23886 | Gdf15 | growth differentiation factor 15 | Mus musculus | Pro-Longevity |
43% ![]() |
Gdf15 |
14599 | Gh | Growth hormone | Mus musculus | Anti-Longevity |
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Gh |
14600 | Ghr | Growth hormone receptor | Mus musculus | Anti-Longevity |
40% ![]() |
Ghr |
14601 | Ghrh | growth hormone releasing hormone | Mus musculus | Anti-Longevity |
46% ![]() |
Ghrh |
14602 | Ghrhr | Growth hormone releasing hormone receptor | Mus musculus | Anti-Longevity |
20% ![]() |
Ghrhr |
2764 | GMFB | glia maturation factor beta | Mus musculus | Anti-Longevity |
6% ![]() |
GMFB |
625249 | Gpx4 | Glutathione peroxidase 4 | Mus musculus | Anti-Longevity |
7% ![]() |
Gpx4 |
14824 | Grn | granulin | Mus musculus | Pro-Longevity |
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Grn |
606496 | Gsk3a | glycogen synthase kinase 3 alpha | Mus musculus | Pro-Longevity |
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Gsk3a |
14860 | Gsta4 | glutathione S-transferase, alpha 4 | Mus musculus | Anti-Longevity |
13% ![]() |
Gsta4 |
15201 | Hells | Proliferation associated SNF-2-like gene | Mus musculus | Pro-Longevity |
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Hells |
11991 | Hnrnpd | heterogeneous nuclear ribonucleoprotein D | Mus musculus | Pro-Longevity |
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Hnrnpd |
15551 | Htr1b | 5-hydroxytryptamine (serotonin) receptor 1B | Mus musculus | Pro-Longevity |
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Htr1b |
64704 | Htra2 | HtrA serine peptidase 2 | Mus musculus | Pro-Longevity |
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Htra2 |
15194 | Htt | Huntingtin | Mus musculus | Anti-Longevity |
18% ![]() |
Htt |
16000 | Igf1 | Insulin-like growth factor 1 | Mus musculus | Unclear |
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Igf1 |
16001 | Igf1r | Insulin-like growth factor 1 receptor | Mus musculus | Anti-Longevity |
40% ![]() |
Igf1r |
16150 | Ikbkb | inhibitor of kappaB kinase beta | Mus musculus | Anti-Longevity |
23% ![]() |
Ikbkb |
16337 | Insr | Insulin receptor | Mus musculus | Anti-Longevity |
33% ![]() |
Insr |
16367 | Irs1 | insulin receptor substrate 1 | Mus musculus | Anti-Longevity |
18% ![]() |
Irs1 |
384783 | Irs2 | insulin receptor substrate 2 | Mus musculus | Anti-Longevity |
18% ![]() |
Irs2 |
16478 | Jund | Jun proto-oncogene related gene d | Mus musculus | Pro-Longevity |
17% ![]() |
Jund |
16491 | Kcna3 | Potassium voltage-gated channel, shaker-related subfamily, member 3 | Mus musculus | Anti-Longevity |
22% ![]() |
Kcna3 |
16591 | Kl | Klotho | Mus musculus | Pro-Longevity |
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Kl |
16905 | Lmna | lamin A | Mus musculus | Unclear |
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Lmna |
17216 | Mcm2 | minichromosome maintenance deficient 2 mitotin (S. cerevisiae) | Mus musculus | Pro-Longevity |
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Mcm2 |
107895 | Mgat5 | mannoside acetylglucosaminyltransferase 5 | Mus musculus | Pro-Longevity |
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Mgat5 |
17319 | Mif | macrophage migration inhibitory factor | Mus musculus | Anti-Longevity |
16% ![]() |
Mif |
723905 | Mir17 | microRNA 17 | Mus musculus | Pro-Longevity |
16% ![]() |
Mir17 |
387222 | Mir29a | microRNA 29a | Mus musculus | Unannotated | Mir29a | |
17685 | Msh2 | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | Mus musculus | Pro-Longevity |
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Msh2 |
110265 | Msra | Methionine sulfoxide reductase A | Mus musculus | Pro-Longevity |
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Msra |
17700 | Mstn | myostatin | Mus musculus | Anti-Longevity |
15% ![]() |
Mstn |
17748 | Mt1 | metallothionein 1 | Mus musculus | Pro-Longevity |
14% ![]() |
Mt1 |
105837 | Mtbp | Mdm2, transformed 3T3 cell double minute p53 binding protein | Mus musculus | Anti-Longevity |
20% ![]() |
Mtbp |
56717 | Mtor | mechanistic target of rapamycin (serine/threonine kinase) | Mus musculus | Anti-Longevity |
20% ![]() |
Mtor |
17869 | Myc | myelocytomatosis oncogene | Mus musculus | Anti-Longevity |
21% ![]() |
Myc |
20602 | Ncor2 | nuclear receptor co-repressor 2 | Mus musculus | Pro-Longevity |
50% ![]() |
Ncor2 |
72774 | Neil1 | nei endonuclease VIII-like 1 (E. coli) | Mus musculus | Pro-Longevity |
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Neil1 |
18033 | Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus | Pro-Longevity |
33% ![]() |
Nfkb1 |
18127 | Nos3 | nitric oxide synthase 3, endothelial cell | Mus musculus | Pro-Longevity |
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Nos3 |
4521 | NUDT1 | nudix (nucleoside diphosphate linked moiety X)-type motif 1 | Mus musculus | Pro-Longevity |
16% ![]() |
NUDT1 |
18491 | Pappa | Pregnancy-associated plasma protein A | Mus musculus | Anti-Longevity |
30% ![]() |
Pappa |
11545 | Parp1 | ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) | Mus musculus | Unannotated |
25% ![]() |
Parp1 |
114774 | Pawr | PRKC, apoptosis, WT1, regulator | Mus musculus | Pro-Longevity |
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Pawr |
18534 | Pck1 | phosphoenolpyruvate carboxykinase 1, cytosolic | Mus musculus | Pro-Longevity |
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Pck1 |
18627 | Per2 | period circadian clock 2 | Mus musculus | Anti-Longevity |
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Per2 |
18792 | Plau | Plasminogen activator, urokinase | Mus musculus | Pro-Longevity |
20% ![]() |
Plau |
18975 | Polg | Polymerase (DNA directed), gamma | Mus musculus | Pro-Longevity |
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Polg |
18736 | Pou1f1 | POU domain, class 1, transcription factor 1 | Mus musculus | Anti-Longevity |
40% ![]() |
Pou1f1 |
19016 | Pparg | Peroxisome proliferator activated receptor gamma | Mus musculus | Pro-Longevity |
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Pparg |
53892 | Ppm1d | protein phosphatase 1D magnesium-dependent, delta isoform | Mus musculus | Pro-Longevity |
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Ppm1d |
18477 | Prdx1 | Peroxiredoxin 1 | Mus musculus | Pro-Longevity |
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Prdx1 |
19088 | Prkar2b | protein kinase, cAMP dependent regulatory, type II beta | Mus musculus | Anti-Longevity |
14% ![]() |
Prkar2b |
19127 | Prop1 | Prophet of Pit1, paired-like homeodomain transcription factor | Mus musculus | Anti-Longevity |
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Prop1 |
19211 | Pten | Phosphatase and tensin homolog | Mus musculus | Pro-Longevity |
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Pten |
66679 | Rae1 | RAE1 RNA export 1 homolog (S. pombe) | Mus musculus | Pro-Longevity |
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Rae1 |
56190 | Rbm38 | RNA binding motif protein 38 | Mus musculus | Pro-Longevity |
22% ![]() |
Rbm38 |
78757 | Rictor | RPTOR independent companion of MTOR, complex 2 | Mus musculus | Pro-Longevity |
40% ![]() |
Rictor |
72508 | Rps6kb1 | ribosomal protein S6 kinase, polypeptide 1 | Mus musculus | Anti-Longevity |
19% ![]() |
Rps6kb1 |
18787 | Serpine1 | serine (or cysteine) peptidase inhibitor, clade E, member 1 | Mus musculus | Anti-Longevity |
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Serpine1 |
20416 | Shc1 | SHC (Src homology 2 domain containing) transforming protein 1 | Mus musculus | Anti-Longevity |
30% ![]() |
Shc1 |
83382 | Siglece | sialic acid binding Ig-like lectin E | Mus musculus | Pro-Longevity |
17% ![]() |
Siglece |
93759 | Sirt1 | Sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae) | Mus musculus | Pro-Longevity |
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Sirt1 |
50721 | Sirt6 | sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae) | Mus musculus | Pro-Longevity |
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Sirt6 |
209011 | Sirt7 | Sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae) | Mus musculus | Pro-Longevity |
59% ![]() |
Sirt7 |
55961 | Slc13a1 | Solute carrier family 13 (sodium/sulfate symporters), member 1 | Mus musculus | Anti-Longevity |
25% ![]() |
Slc13a1 |
11739 | Slc25a4 | solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 | Mus musculus | Pro-Longevity |
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Slc25a4 |
216233 | Socs2 | Suppressor of cytokine signaling 2 | Mus musculus | Pro-Longevity |
35% ![]() |
Socs2 |
20656 | Sod2 | Superoxide dismutase 2, mitochondrial | Mus musculus | Pro-Longevity |
43% ![]() |
Sod2 |
6649 | SOD3 | superoxide dismutase 3 | Mus musculus | Pro-Longevity |
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SOD3 |
18412 | Sqstm1 | sequestosome 1 | Mus musculus | Pro-Longevity |
34% ![]() |
Sqstm1 |
56424 | Stub1 | STIP1 homology and U-Box containing protein 1 | Mus musculus | Pro-Longevity |
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Stub1 |
20930 | Surf1 | surfeit gene 1 | Mus musculus | Anti-Longevity |
20% ![]() |
Surf1 |
21750 | Terf2 | telomeric repeat binding factor 2 | Mus musculus | Anti-Longevity |
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Terf2 |
21752 | Tert | Telomerase reverse transcriptase | Mus musculus | Pro-Longevity |
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Tert |
21976 | Top3b | Topoisomerase (DNA) III beta | Mus musculus | Pro-Longevity |
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Top3b |
106021 | Topors | Topoisomerase I binding, arginine/serine-rich | Mus musculus | Pro-Longevity |
42% ![]() |
Topors |
22019 | Tpp2 | Tripeptidyl peptidase II | Mus musculus | Pro-Longevity |
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Tpp2 |
22059 | Trp53 | Transformation related protein 53 | Mus musculus | Pro-Longevity |
23% ![]() |
Trp53 |
27223 | Trp53bp1 | Transformation related protein 53 binding protein 1 | Mus musculus | Anti-Longevity |
![]() |
Trp53bp1 |
22061 | Trp63 | Transformation related protein 63 | Mus musculus | Pro-Longevity |
70% ![]() |
Trp63 |
22062 | Trp73 | transformation related protein 73 | Mus musculus | Pro-Longevity |
31% ![]() |
Trp73 |
193034 | Trpv1 | transient receptor potential cation channel, subfamily V, member 1 | Mus musculus | Anti-Longevity |
16% ![]() |
Trpv1 |
22166 | Txn1 | Thioredoxin 1 | Mus musculus | Pro-Longevity |
35% ![]() |
Txn1 |
24108 | Ubd | ubiquitin D | Mus musculus | Anti-Longevity |
20% ![]() |
Ubd |
22228 | Ucp2 | uncoupling protein 2 (mitochondrial, proton carrier) | Mus musculus | Pro-Longevity |
20% ![]() |
Ucp2 |
22590 | Xpa | Xeroderma pigmentosum, complementation group A | Mus musculus | Pro-Longevity |
![]() |
Xpa |
22596 | Xrcc5 | X-ray repair complementing defective repair in Chinese hamster cells 5 | Mus musculus | Pro-Longevity |
40% ![]() |
Xrcc5 |
14375 | Xrcc6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | Mus musculus | Pro-Longevity |
![]() |
Xrcc6 |
230709 | Zmpste24 | zinc metallopeptidase, STE24 homolog (S. cerevisiae) | Mus musculus | Pro-Longevity |
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Zmpste24 |