- Symbol
- Rictor
- Name
- RPTOR independent companion of MTOR, complex 2
- Organism
- Mus musculus (AnAge)
- Observations
- Heterozygous male rictor+/- mice display a significantly decrease in median lifespan (40%) compared to wild-type controls. Liver- specific deletion of Rictor in male mice also resulted in a 30% decrease in median lifespan. In both models, the decrease in lifespan was associated by a decrease in the incidence of cancer. Inducibly deleting Rictor throughout the body in adult animals, results in a stronger phenotype with a median survival of less than 1 year. No significant changes were observed for female lifespan in any of the three models.
- % change in avg or median lifespan
- Median lifespan of Rictor-deficient mice was up to 40% lower in males. Lifespan was not affected in females.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Depletion
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as rict-1
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as RICTOR
- GenAge microarray genes
- A homolog of this gene for Homo sapiens is present as RICTOR
- LongevityMap
- A homolog of this gene for Homo sapiens is present as RICTOR
- Caenorhabditis elegans
- rict-1
- Danio rerio
- rictorb
- Danio rerio
- rictora
- Drosophila melanogaster
- rictor
- Homo sapiens
- RICTOR
- Rattus norvegicus
- Rictor
- Saccharomyces cerevisiae
- TSC11
- Schizosaccharomyces pombe
- ste16
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (78757)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar