- Symbol
- Insr
- Aliases
- IR; IR-A; IR-B; CD220; 4932439J01Rik; D630014A15Rik
- Name
- Insulin receptor
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- Signal tranduction of insulin
- Observations
- Deletion in adipose tissue increased lifespan.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Deletion
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Homologous murine model was created by replacing Pro-1195 of insulin receptors with Leu. Homozygous mice died in the neonatal stage from diabetic ketoacidosis, whereas heterozygous mice showed the suppressed kinase activity of the insulin receptor but grew normally without spontaneously developing diabetes during adulthood. Under 80% oxygen, mutant female mice survived 33.3% longer than wild-type female mice, whereas mutant male mice survived 18.2% longer than wild-type male mice.
- % change in avg or median lifespan
- Female average lifespan is 33.3% higher; Male average lifespan is 18.2% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutations
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as daf-2
- A homolog of this gene for Drosophila melanogaster is present as InR
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as INSR
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as InR
- A homolog of this gene for Caenorhabditis elegans is present as daf-2
- LongevityMap
- A homolog of this gene for Homo sapiens is present as INSR
- Caenorhabditis elegans
- daf-2
- Danio rerio
- insra
- Danio rerio
- insrb
- Drosophila melanogaster
- InR
- Homo sapiens
- INSR
- Rattus norvegicus
- Insr
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (16337)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar