- Symbol
- Polg
- Aliases
- PolgA; AA409516
- Name
- Polymerase (DNA directed), gamma
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- Involved in mitochondrial DNA replication and repair
- Observations
- Mice with a proof-reading-deficient version of Polg display an increased amount of mtDNA mutations and signs of premature ageing including a reduced lifespan, weight loss, reduced subcutaneous fat, alopecia, kyphosis, osteoporosis, anaemia, reduced fertility, and heart enlargement.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutations
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Mice with a proofreading-deficient version of the mitochondrial DNA polymerase g (POLG) resulted in premature aging and cancer.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutations
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as POLG
- LongevityMap
- A homolog of this gene for Homo sapiens is present as POLG
- Caenorhabditis elegans
- polg-1
- Danio rerio
- polg
- Drosophila melanogaster
- tam
- Homo sapiens
- POLG
- Rattus norvegicus
- Polg
- Saccharomyces cerevisiae
- MIP1
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (18975)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Polg (Mus musculus)