- Symbol
- Brca1
- Name
- Breast cancer 1
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- Maintenance of genomic stability
- Observations
- Deletion causes senescence in mutant embryos and cultured cells and tumorigenesis and signs of premature ageing in adult mice.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Deletion
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Brca1 heterozygotes appear to have a shortened life span with 70% tumor incidence. Lymphoma, but not ovarian and mammary gland tumors, occurs commonly in these mice. After a whole-body exposure to ionizing radiation, Brca1 heterozygous mice have a 3-5-fold higher incidence specific to ovarian tumors, but not lymphoma, when compared with the Brca1+/+ mice.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Deletion
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as BRCA1
- LongevityMap
- A homolog of this gene for Homo sapiens is present as BRCA1
- CellAge
- A homolog of this gene for Homo sapiens is present as BRCA1
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as BRCA1
- Homo sapiens
- BRCA1
- Rattus norvegicus
- Brca1
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (12189)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Brca1 (Mus musculus)