- Symbol
- Irs1
- Aliases
- G972R; IRS-1
- Name
- insulin receptor substrate 1
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- Cytoplasmic signalling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines
- Observations
- Median lifespan was extended 18% in knockouts from both sexes and 32% in females. Female animals displayed signs of resistance to ageing markers in skin, bone, immune system, and motor dysfunction, in spite of mild, lifelong insulin resistance. Heterozygous animals had normal lifespans.
- % change in avg or median lifespan
- Median lifespan is 18% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Knockout
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as chico
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as IRS1
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as chico
- LongevityMap
- A homolog of this gene for Homo sapiens is present as IRS1
- Danio rerio
- irs1
- Drosophila melanogaster
- chico
- Homo sapiens
- IRS1
- Rattus norvegicus
- Irs1
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (16367)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Irs1 (Mus musculus)