- Symbol
- Kcna3
- Aliases
- Mk-3; Kv1.3; Kca1-3
- Name
- Potassium voltage-gated channel, shaker-related subfamily, member 3
- Organism
- Mus musculus (AnAge)
- Observations
- Kv1.3-null mice weigh less than their WT counterparts, have modified ingestive behaviors, are resistant to fat deposition following a moderately high-fat dietary regime and have improved longevity and fecundity. Moreover, gene-targeted deletion of Kv1.3 in MC4R-null mice (36% shorter lifespan compared to WT) returned the lifespan of these mice to approximately WT levels.
- % change in avg or median lifespan
- Average lifespan is 22% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Deletion
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as KCNA3
- GenDR gene manipulations
- A homolog of this gene for Caenorhabditis elegans is present as shk-1
- Caenorhabditis elegans
- shk-1
- Danio rerio
- KCNA3
- Drosophila melanogaster
- Sh
- Homo sapiens
- KCNA3
- Rattus norvegicus
- Kcna3
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (16491)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Kcna3 (Mus musculus)