GenAge entry for PROP1 (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 5)
- HGNC symbol
- PROP1
- Aliases
- Common name
- PROP paired-like homeobox 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
A transcription factor involved in hormonal regulation and development, PROP1 sits upstream of POU1F1 [355]. The Ames dwarf, a mouse strain mutant for PROP1, is remarkably long-lived with some evidence of delayed ageing [10]. On the other hand, PROP1 mutations in mice are strongly influenced by genetic background and can be lethal in some cases [1802]. Human mutations in PROP1 result in pituitary hormone deficiency, typically characterized by growth retardation. Although some individuals may be long-lived 0142, it is not known to what extent and in what direction PROP1 mutations affect the human ageing process [1345].
Cytogenetic information
- Cytogenetic band
- 5q35.3
- Location
- 177,992,235 bp to 177,996,242 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001568; blood vessel development
GO:0006366; transcription from RNA polymerase II promoter
GO:0007417; central nervous system development
GO:0009953; dorsal/ventral pattern formation
GO:0016477; cell migration
GO:0021979; hypothalamus cell differentiation
GO:0043066; negative regulation of apoptotic process
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0048850; hypophysis morphogenesis
GO:0060070; canonical Wnt signaling pathway
And 2 more GO terms Cellular component: GO:0005634; nucleus
GO:0005667; transcription factor complex
Function: GO:0000980; RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001205; transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001206; transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003682; chromatin binding
GO:0005515; protein binding
GO:0008013; beta-catenin binding
GO:0008022; protein C-terminus binding
Protein interactions and network
Retrieve sequences for PROP1
Homologs in model organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Prop1
- GenDR gene manipulations
- A homolog of this gene for Mus musculus is present as Prop1
Selected references
External links
- EPD
- ORF Accession
- NM_006261
- CDS Accession
- NP_006252
- OMIM
- 601538
- HPRD
- 03325
- Ensembl
- PROP1
- UniProt/Swiss-Prot
- PROP1_HUMAN
- GeneCards
- PROP1
- Entrez Gene
- 5626
- GenAtlas
- PROP1
- Internet
- Search Google