GenDR Dietary Restriction Gene Manipulation: Prop1
Gene Information (Entrez Gene ID: 19127)
- Symbol
- Prop1
- Aliases
- df Prop-1
- Name
- paired like homeodomain factor 1
- Organism
- Mus musculus (AnAge)
- Entrez Gene ID
- 19127
Potential relevance to dietary restriction and ageing
- Observations
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Methionine restriction (a form of dietary restriction) enhances lifespan in various organisms including mammals. GH-deficient Ames dwarfs, mice that have a mutation in the Prop-1 gene, live longer than wild-type mice when their diet contains 0.43% or 1.3% methionine. Contrastly, there is no significant difference in lifespan on a diet of 0.16% methionine, wild-type mice being under these conditions long-lived as well. This suggests that lifespan extension by methionine restriction might work through similar mechanisms as those confering Ames mice greater lifespan.
- References
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In other databases
- GenAge model organism genes
- This gene is present as Prop1
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as PROP1
Homologs
External links
- Mouse Genome Informatics
- Search
- Ensembl
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- Entrez Gene
- ID 19127
- Homologues
- Search HomoloGene
- UniProt
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- Internet
- Search Google or Search Google Scholar