Mus musculus GenDR Dietary Restriction Gene Manipulation: Prop1

Gene Information (Entrez Gene ID: 19127)

Symbol
Prop1
Aliases
df Prop-1
Name
paired like homeodomain factor 1
Organism
Mus musculus (AnAge)
Entrez Gene ID
19127

Potential relevance to dietary restriction and ageing

Observations

Methionine restriction (a form of dietary restriction) enhances lifespan in various organisms including mammals. GH-deficient Ames dwarfs, mice that have a mutation in the Prop-1 gene, live longer than wild-type mice when their diet contains 0.43% or 1.3% methionine. Contrastly, there is no significant difference in lifespan on a diet of 0.16% methionine, wild-type mice being under these conditions long-lived as well. This suggests that lifespan extension by methionine restriction might work through similar mechanisms as those confering Ames mice greater lifespan.

References

    In other databases

    GenAge model organism genes
    • This gene is present as Prop1
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as PROP1

    Homologs

    Caenorhabditis elegans
    unc-42
    Drosophila melanogaster
    CG32532
    Homo sapiens
    PROP1
    Rattus norvegicus
    Prop1

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    ID 19127
    Homologues
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    UniProt
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    Internet
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