Drosophila melanogaster GenDR Dietary Restriction Gene Manipulation: Indy

Gene Information (Entrez Gene ID: 40049)

Symbol
Indy
Aliases
anon-EST:fe3A7 anon-WO0172774.70 BEST:LP01220 CG3979 Dmel\CG3979 drIndy indy INDY
Name
I'm not dead yet
Organism
Drosophila melanogaster (AnAge)
Entrez Gene ID
40049

Potential relevance to dietary restriction and ageing

Observations

Flies heterozygotic for a disruption in Indy gene have extended mean (87-92%) and maximum (45%) lifespan. Homozygotes for the disruption show only a 10 - 20% increase in mean lifespan [2173]. Heterozygous insertion of a p-element in the non-coding region of Indy locus leads to a reduction in Indy mRNA expression and causes a significant median lifespan extension in male and female by about 29% and 34%, respectively. At normal or high calorie conditions Indy heterozygote mutants have a significant lifespan extension, but under low calorie conditions, Indy heterozygous mutants have minimal median lifespan extension. Indy mutation alters metabolism in a manner similar to DR and mutants have several phenotypes with long-lived DR files in common, including decreases insulin-like signalling, lipid storage, weight gain, and resistance to starvation, and an increase in spontaneous physical activity [2577].

References

    In other databases

    GenAge model organism genes
    • This gene is present as Indy
    • A homolog of this gene for Caenorhabditis elegans is present as nac-2
    • A homolog of this gene for Mus musculus is present as Slc13a1
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as SLC13A1
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as SLC13A2
    CellAge
    • A homolog of this gene for Homo sapiens is present as SLC13A3

    Homologs

    Caenorhabditis elegans
    B0285.6
    Caenorhabditis elegans
    nac-2
    Danio rerio
    slc13a3
    Danio rerio
    slc13a2
    Danio rerio
    slc13a4
    Danio rerio
    slc13a5a
    Danio rerio
    slc13a1
    Danio rerio
    slc13a5b
    Homo sapiens
    SLC13A2
    Homo sapiens
    SLC13A3
    Homo sapiens
    SLC13A5
    Homo sapiens
    SLC13A1
    Homo sapiens
    SLC13A4
    Mus musculus
    Slc13a3
    Mus musculus
    Slc13a5
    Mus musculus
    Slc13a1
    Mus musculus
    Slc13a2
    Mus musculus
    Slc13a4
    Rattus norvegicus
    Slc13a5
    Rattus norvegicus
    Slc13a4
    Rattus norvegicus
    Slc13a3
    Rattus norvegicus
    Slc13a2
    Rattus norvegicus
    Slc13a1
    Schizosaccharomyces pombe
    SPBC3B8.04c

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    ID 40049
    Homologues
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    UniProt
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    Internet
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