Cell Senescence Entries for SLC13A3
- Cell Types
- Lung fibroblast, Renal tubular
- Cell Lines
- MRC-5, WI-38
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Stress-induced
- Senescence Effect
- Induces
- Primary Reference
- Ma et al. (2016) NaDC3 Induces Premature Cellular Senescence by Promoting Transport of Krebs Cycle Intermediates, Increasing NADH, and Exacerbating Oxidative Damage. J Gerontol A Biol Sci Med Sci 71(1)1-12 (PubMed)
SLC13A3 Gene Information
- HGNC symbol
- SLC13A3
- Aliases
- NADC3; SDCT2
- Common name
- solute carrier family 13 member 3
- Entrez Id
- 64849
- Description
- Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet. [provided by RefSeq, Jul 2008].
SLC13A3 Ontologies
- Gene Ontology
-
Process: GO:55085; transmembrane transport
GO:6811; ion transport
GO:6814; sodium ion transport
GO:150104; transport across blood-brain barrier
GO:34775; glutathione transmembrane transport
GO:15742; alpha-ketoglutarate transport
GO:71422; succinate transmembrane transport
GO:98656; anion transmembrane transport
GO:15746; citrate transport
GO:6835; dicarboxylic acid transport
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:70062; extracellular exosome
GO:16323; basolateral plasma membrane
Function: GO:22857; transmembrane transporter activity
GO:15293; symporter activity
GO:5515; protein binding
GO:34634; glutathione transmembrane transporter activity
GO:15141; succinate transmembrane transporter activity
GO:15137; citrate transmembrane transporter activity
GO:17153; sodium:dicarboxylate symporter activity
GO:5310; dicarboxylic acid transmembrane transporter activity
GO:15139; alpha-ketoglutarate transmembrane transporter activity
GO:15362; high-affinity sodium:dicarboxylate symporter activity
Homologs of SLC13A3 in Model Organisms
- Caenorhabditis elegans
- nac-3
- Caenorhabditis elegans
- nac-1
- Danio rerio
- slc13a3
- Drosophila melanogaster
- CG33934
- Drosophila melanogaster
- Indy-2
- Drosophila melanogaster
- CG7309
- Drosophila melanogaster
- Indy
- Mus musculus
- Slc13a3
- Rattus norvegicus
- Slc13a3
- Schizosaccharomyces pombe
- SPBC3B8.04c
In other databases
- GenAge model organism genes
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as Indy
External links
- OMIM
- 606411
- Ensembl
- ENSG00000158296
- Entrez Gene
- 64849
- UniGene
- 670365
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SLC13A3
- GeneCards
- SLC13A3