Release date: April 23, 2023
Number of genes inferred from genetic manipulations: 866
Number of genes from expression changes: 1,259
Build 3 represents a significant update. The number of manually-curated genes associated with cellular senescence has more than tripled compared to the previous build. The gene expression signature of replicative senescence derived from a meta-analysis of human microarray data remains unchanged.
Please remember these notes refer to the latest stable build of CellAge. The current CellAge stats may differ slightly from the above due to improvements after the build's release.
More information concerning the design and curation of CellAge is available elsewhere. Use of the CellAge is free but subject to the conditions of the Human Ageing Genomic Resources. To cite CellAge please use:
Avelar, R. A., Ortega, J. G., Tacutu, R., Tyler, E. J., Bennett, D., Binetti, P., Budovsky, A., Chatsirisupachai, K., Johnson, E., Murray, A., Shields, S., Tejada-Martinez, D., Thornton, D., Fraifeld, V. E., Bishop, C. L., & de Magalhaes, J. P. (2020) "A multidimensional systems biology analysis of cellular senescence in aging and disease." Genome Biology 21(1):91.
If you only use the gene expression signature of cellular senescence, please cite:
Chatsirisupachai, K., Palmer, D., Ferreira, S., & de Magalhaes, J. P. (2019) "A human tissue-specific transcriptomic analysis reveals a complex relationship between aging, cancer, and cellular senescence." Aging Cell 18(6):e13041.
Comments, suggestions, ideas, and bug reports are welcome. Please contact us.