GenAge entry for SLC13A1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 270)

HGNC symbol: SLC13A1
Aliases: NaSi-1; NAS1
Common name: solute carrier family 13 (sodium/sulfate symporter), member 1

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Description

SLC13A1, also known as NaS1, is one of the members of the solute carrier family (sodium/sulfate symporters) and has a role in mediating sulfate reabsorption in the kidney. It appears to be involved in kidney disease.

Knockout NaS1 mice (Nas1 -/- ) were found to live longer and have less tumors in aged mice. Median lifespans was increased in both male and female mice when compared with wild type [2172]. Similar results were observed for orthologs of SLC13A1 in flies [2173] and worm [2174]. Therefore, results from model systems support a role for SLC13A1 in ageing, although further studies are necessary to determine if it also plays a role in human ageing.

Cytogenetic information

Cytogenetic band: 7q31.32
Location: 123,113,534 bp to 123,199,971 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0008272; sulfate transport
GO:0035725; sodium ion transmembrane transport
GO:1902358; sulfate transmembrane transport

Cellular component:

GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane

Function:

GO:0015382; sodium:sulfate symporter activity

Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for SLC13A1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: nac-1
Caenorhabditis elegans: nac-3
Danio rerio: slc13a1
Drosophila melanogaster: CG33934
Drosophila melanogaster: Indy-2
Drosophila melanogaster: Indy
Drosophila melanogaster: CG7309
Mus musculus: Slc13a1
Rattus norvegicus: Slc13a1

In other databases

GenAge model organism genes

A homolog of this gene for Drosophila melanogaster is present as Indy
A homolog of this gene for Caenorhabditis elegans is present as nac-3
A homolog of this gene for Mus musculus is present as Slc13a1

GenDR gene manipulations

A homolog of this gene for Drosophila melanogaster is present as Indy