LongevityMap Gene
Gene details
- HGNC symbol
- SLC13A2
- Aliases
- NaCT; NADC1; SDCT1; NaDC-1
- Common name
- solute carrier family 13 member 2
- Description
- The protein encoded by this gene is a sodium-coupled citrate transporter that is regulated by the chaperone activity of cyclophilin b. The encoded protein may play a role in the formation of kidney stones. [provided by RefSeq, Oct 2016]
- Cytogenetic Location
- 17q11.2
- UCSC Genome Browser
- View 17q11.2 on the UCSC genome browser
- OMIM
- 604148
- Ensembl
- ENSG00000007216
- UniProt/Swiss-Prot
- S13A2_HUMAN
- Entrez Gene
- 9058
- UniGene
- 102307
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- nac-1
- Caenorhabditis elegans
- nac-3
- Danio rerio
- slc13a2
- Drosophila melanogaster
- CG33934
- Drosophila melanogaster
- Indy-2
- Drosophila melanogaster
- CG7309
- Drosophila melanogaster
- Indy
- Mus musculus
- Slc13a2
- Rattus norvegicus
- Slc13a2
In other databases
- GenAge model organism genes
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as Indy
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American
- Study Design
- The gene was sequenced in 13 subjects of age 90-99, 12 subjects between age 38-49 and 18 subjects age <23. The I550V polymorphism was genotyped in 2366 subjects and examined for its association with age.
- Conclusions
- An examination of 1338 female and 684 male white subjects demonstrated that the 1648 A/G (I550V) mutation was not associated with a greater longevity
- Indentifier
- I550V
- Reference