LongevityMap variant

Entry Details

Longevity Association: Significant
Population: Danish
Study Design: SNPs rs4880 in MnSOD and rs1050450 in GPX1 were genotyped in 1650 individuals from the Danish 1905 cohort (follow-up time: 1998–2008, age at intake: 92–93 years, number of deaths: 1589 (96.3%)) and investigated for the association with aging and longevity
Conclusions: Decreased mortality of individuals holding either the MnSOD rs4880 C or the GPX1 rs1050450 T alleles (HR (MnSOD(CC/CT)) = 0.91, p = 0.002), HR (GPX1(TT/TC)) = 0.93, p = 0.008)) was observed, as well as a synergetic effect (HR = 0.76, p = 0.001). Genetic variation in MnSOD and GPX1 may be associated with aging and longevity.

HGNC symbol: SOD2
Aliases: IPOB; IPO-B; MNSOD; MVCD6; Mn-SOD
Common name: superoxide dismutase 2
Description: This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]
Other longevity studies of this gene: 21
OMIM: 147460
Ensembl: ENSG00000112096
UniProt/Swiss-Prot: A0A0C4DFU1_HUMAN
Entrez Gene: 6648
UniGene: 487046
HapMap: View on HapMap

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Soerensen et al. (2009)