- Symbol
- sod-2
- Name
- Superoxide dismutase (24.5 kD) (sod-2)
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- Treatment of wild-type worms increased their mean LS by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their LS (a 67 percent increase).
- % change in avg or median lifespan
- Average lifespan is 44% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Pharmacological overexpression (Superoxide dismutase/catalase mimetics)
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- sod-2 mutants are long-lived (maximum lifespan increased by 30%) despite a significant increase in oxidatively damaged proteins. The lifespan of sod1, sod3, sod4 and sod5 mutants was not affected. Examination of worm lifespan revealed that sod-1; sod-3; sod-5 mutant worms live as long as wild-type worms while both sod-2; sod-3; sod-5 and sod-1; sod-2; sod- 4 mutant worms live significantly longer than wild-type (maximum lifespan increased by 30%).
- % change in max lifespan
- Maximum lifespan is 30% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutations
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as SOD2
- A homolog of this gene for Drosophila melanogaster is present as Sod2
- A homolog of this gene for Mus musculus is present as Sod2
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as SOD2
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as SOD2
- LongevityMap
- A homolog of this gene for Homo sapiens is present as SOD2
- CellAge
- A homolog of this gene for Homo sapiens is present as SOD2
- Danio rerio
- sod2
- Drosophila melanogaster
- Sod2
- Homo sapiens
- SOD2
- Homo sapiens
- SOD2
- Mus musculus
- Sod2
- Rattus norvegicus
- Sod2
- Saccharomyces cerevisiae
- SOD2
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (172632)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar