Ageing-Associated Genes in Model Organisms
Found 136 results. Showing results 1 to 136.
| Entrez ID | Symbol | Name | Organism | Longevity influence | Max average lifespan change | More details |
|---|---|---|---|---|---|---|
| 224129 | Adcy5 | adenylate cyclase 5 | Mus musculus | Anti-Longevity |
30%  |
Adcy5 |
| 11549 | Adra1a | adrenergic receptor, alpha 1a | Mus musculus | Pro-Longevity |
10% |
Adra1a |
| 11548 | Adra1b | adrenergic receptor, alpha 1b | Mus musculus | Anti-Longevity |
11%  |
Adra1b |
| 11607 | Agtr1a | Angiotensin II receptor, type 1a | Mus musculus | Anti-Longevity |
26% |
Agtr1a |
| 11651 | Akt1 | thymoma viral proto-oncogene 1 | Mus musculus | Anti-Longevity |
12% |
Akt1 |
| 11652 | Akt2 | thymoma viral proto-oncogene 2 | Mus musculus | Anti-Longevity |
9% |
Akt2 |
| 11816 | Apoe | Apolipoprotein E | Mus musculus | Pro-Longevity |
|
Apoe |
| 228359 | Arhgap1 | Rho GTPase activating protein 1 | Mus musculus | Pro-Longevity |
|
Arhgap1 |
| 11865 | Arntl | aryl hydrocarbon receptor nuclear translocator-like | Mus musculus | Pro-Longevity |
|
Arntl |
| 11793 | Atg5 | autophagy related 5 | Mus musculus | Pro-Longevity |
17% |
Atg5 |
| 11920 | Atm | Ataxia telangiectasia mutated homolog (human) | Mus musculus | Pro-Longevity |
|
Atm |
| 245000 | Atr | Ataxia telangiectasia and Rad3 related | Mus musculus | Pro-Longevity |
|
Atr |
| 12028 | Bax | Bcl2-associated X protein | Mus musculus | Unannotated |
|
Bax |
| 12189 | Brca1 | Breast cancer 1 | Mus musculus | Pro-Longevity |
|
Brca1 |
| 12236 | Bub1b | budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) | Mus musculus | Pro-Longevity |
 |
Bub1b |
| 12237 | Bub3 | budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae) | Mus musculus | Pro-Longevity |
12% |
Bub3 |
| 12366 | Casp2 | caspase 2 | Mus musculus | Pro-Longevity |
|
Casp2 |
| 12359 | Cat | Catalase | Mus musculus | Pro-Longevity |
21% |
Cat |
| 12389 | Cav1 | caveolin, caveolae protein 1 | Mus musculus | Pro-Longevity |
50% |
Cav1 |
| 218294 | Cdc14b | CDC14 cell division cycle 14B | Mus musculus | Pro-Longevity | Cdc14b | |
| 12572 | Cdk7 | cyclin-dependent kinase 7 | Mus musculus | Pro-Longevity |
|
Cdk7 |
| 12575 | Cdkn1a | Cyclin-dependent kinase inhibitor 1A | Mus musculus | Anti-Longevity |
|
Cdkn1a |
| 12606 | Cebpa | CCAAT/enhancer binding protein (C/EBP), alpha | Mus musculus | Unannotated |
|
Cebpa |
| 12608 | Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | Mus musculus | Unannotated |
|
Cebpb |
| 50883 | Chek2 | CHK2 checkpoint homolog (S. pombe) | Mus musculus | Pro-Longevity |
|
Chek2 |
| 67006 | Cisd2 | CDGSH iron sulfur domain 2 | Mus musculus | Pro-Longevity |
|
Cisd2 |
| 12753 | Clock | Circadian locomotor output cycles kaput | Mus musculus | Pro-Longevity |
15% |
Clock |
| 12842 | Col1a1 | collagen, type I, alpha 1 | Mus musculus | Pro-Longevity |
|
Col1a1 |
| 12850 | Coq7 | demethyl-Q 7 | Mus musculus | Anti-Longevity |
30% |
Coq7 |
| 13019 | Ctf1 | cardiotrophin 1 | Mus musculus | Anti-Longevity |
18% |
Ctf1 |
| 13350 | Dgat1 | diacylglycerol O-acyltransferase 1 | Mus musculus | Anti-Longevity |
23% |
Dgat1 |
| 13405 | Dmd | Dystrophin, muscular dystrophy | Mus musculus | Pro-Longevity |
18% |
Dmd |
| 66143 | Eef1e1 | Eukaryotic translation elongation factor 1 epsilon 1 | Mus musculus | Anti-Longevity |
50% |
Eef1e1 |
| 216616 | Efemp1 | Epidermal growth factor-containing fibulin-like extracellular matrix protein 1 | Mus musculus | Pro-Longevity |
20% |
Efemp1 |
| 208691 | Eif5a2 | eukaryotic translation initiation factor 5A2 | Mus musculus | Anti-Longevity |
|
Eif5a2 |
| 13860 | Eps8 | Epidermal growth factor receptor pathway substrate 8 | Mus musculus | Anti-Longevity |
37% |
Eps8 |
| 13870 | Ercc1 | excision repair cross-complementing rodent repair deficiency, complementation group 1 | Mus musculus | Pro-Longevity |
83% |
Ercc1 |
| 13871 | Ercc2 | Excision repair cross-complementing rodent repair deficiency, complementation group 2 | Mus musculus | Pro-Longevity |
|
Ercc2 |
| 50505 | Ercc4 | Excision repair cross-complementing rodent repair deficiency, complementation group 4 | Mus musculus | Pro-Longevity |
|
Ercc4 |
| 56636 | Fgf21 | fibroblast growth factor 21 | Mus musculus | Pro-Longevity |
36% |
Fgf21 |
| 64654 | Fgf23 | Fibroblast growth factor 23 | Mus musculus | Pro-Longevity |
|
Fgf23 |
| 14268 | Fn1 | Fibronectin 1 | Mus musculus | Pro-Longevity |
|
Fn1 |
| 14235 | Foxm1 | Forkhead box M1 | Mus musculus | Pro-Longevity |
|
Foxm1 |
| 14297 | Fxn | frataxin | Mus musculus | Pro-Longevity |
|
Fxn |
| 2539 | G6PD | glucose-6-phosphate dehydrogenase | Mus musculus | Pro-Longevity |
14% |
G6PD |
| 23886 | Gdf15 | growth differentiation factor 15 | Mus musculus | Pro-Longevity |
43% |
Gdf15 |
| 14599 | Gh | Growth hormone | Mus musculus | Anti-Longevity |
|
Gh |
| 14600 | Ghr | Growth hormone receptor | Mus musculus | Anti-Longevity |
40% |
Ghr |
| 14601 | Ghrh | growth hormone releasing hormone | Mus musculus | Anti-Longevity |
46% |
Ghrh |
| 14602 | Ghrhr | Growth hormone releasing hormone receptor | Mus musculus | Anti-Longevity |
20% |
Ghrhr |
| 2764 | GMFB | glia maturation factor beta | Mus musculus | Anti-Longevity |
6% |
GMFB |
| 625249 | Gpx4 | Glutathione peroxidase 4 | Mus musculus | Anti-Longevity |
7% |
Gpx4 |
| 14824 | Grn | granulin | Mus musculus | Pro-Longevity |
|
Grn |
| 606496 | Gsk3a | glycogen synthase kinase 3 alpha | Mus musculus | Pro-Longevity |
|
Gsk3a |
| 14860 | Gsta4 | glutathione S-transferase, alpha 4 | Mus musculus | Anti-Longevity |
13% |
Gsta4 |
| 15201 | Hells | Proliferation associated SNF-2-like gene | Mus musculus | Pro-Longevity |
|
Hells |
| 11991 | Hnrnpd | heterogeneous nuclear ribonucleoprotein D | Mus musculus | Pro-Longevity |
|
Hnrnpd |
| 15551 | Htr1b | 5-hydroxytryptamine (serotonin) receptor 1B | Mus musculus | Pro-Longevity |
|
Htr1b |
| 64704 | Htra2 | HtrA serine peptidase 2 | Mus musculus | Pro-Longevity |
|
Htra2 |
| 15194 | Htt | Huntingtin | Mus musculus | Anti-Longevity |
18% |
Htt |
| 16000 | Igf1 | Insulin-like growth factor 1 | Mus musculus | Unclear |
|
Igf1 |
| 16001 | Igf1r | Insulin-like growth factor 1 receptor | Mus musculus | Anti-Longevity |
40% |
Igf1r |
| 16150 | Ikbkb | inhibitor of kappaB kinase beta | Mus musculus | Anti-Longevity |
23% |
Ikbkb |
| 16337 | Insr | Insulin receptor | Mus musculus | Anti-Longevity |
33% |
Insr |
| 16367 | Irs1 | insulin receptor substrate 1 | Mus musculus | Anti-Longevity |
18% |
Irs1 |
| 384783 | Irs2 | insulin receptor substrate 2 | Mus musculus | Anti-Longevity |
18% |
Irs2 |
| 16478 | Jund | Jun proto-oncogene related gene d | Mus musculus | Pro-Longevity |
17% |
Jund |
| 16491 | Kcna3 | Potassium voltage-gated channel, shaker-related subfamily, member 3 | Mus musculus | Anti-Longevity |
22% |
Kcna3 |
| 16591 | Kl | Klotho | Mus musculus | Pro-Longevity |
|
Kl |
| 16905 | Lmna | lamin A | Mus musculus | Unclear |
|
Lmna |
| 17216 | Mcm2 | minichromosome maintenance deficient 2 mitotin (S. cerevisiae) | Mus musculus | Pro-Longevity |
|
Mcm2 |
| 107895 | Mgat5 | mannoside acetylglucosaminyltransferase 5 | Mus musculus | Pro-Longevity |
|
Mgat5 |
| 17319 | Mif | macrophage migration inhibitory factor | Mus musculus | Anti-Longevity |
16% |
Mif |
| 723905 | Mir17 | microRNA 17 | Mus musculus | Pro-Longevity |
16% |
Mir17 |
| 387222 | Mir29a | microRNA 29a | Mus musculus | Unannotated | Mir29a | |
| 17685 | Msh2 | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | Mus musculus | Pro-Longevity |
|
Msh2 |
| 110265 | Msra | Methionine sulfoxide reductase A | Mus musculus | Pro-Longevity |
|
Msra |
| 17700 | Mstn | myostatin | Mus musculus | Anti-Longevity |
15% |
Mstn |
| 17748 | Mt1 | metallothionein 1 | Mus musculus | Pro-Longevity |
14% |
Mt1 |
| 105837 | Mtbp | Mdm2, transformed 3T3 cell double minute p53 binding protein | Mus musculus | Anti-Longevity |
20% |
Mtbp |
| 56717 | Mtor | mechanistic target of rapamycin (serine/threonine kinase) | Mus musculus | Anti-Longevity |
20% |
Mtor |
| 17869 | Myc | myelocytomatosis oncogene | Mus musculus | Anti-Longevity |
21% |
Myc |
| 20602 | Ncor2 | nuclear receptor co-repressor 2 | Mus musculus | Pro-Longevity |
50% |
Ncor2 |
| 72774 | Neil1 | nei endonuclease VIII-like 1 (E. coli) | Mus musculus | Pro-Longevity |
|
Neil1 |
| 18033 | Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus | Pro-Longevity |
33% |
Nfkb1 |
| 18127 | Nos3 | nitric oxide synthase 3, endothelial cell | Mus musculus | Pro-Longevity |
|
Nos3 |
| 4521 | NUDT1 | nudix (nucleoside diphosphate linked moiety X)-type motif 1 | Mus musculus | Pro-Longevity |
16% |
NUDT1 |
| 18491 | Pappa | Pregnancy-associated plasma protein A | Mus musculus | Anti-Longevity |
30% |
Pappa |
| 11545 | Parp1 | ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) | Mus musculus | Unannotated |
25% |
Parp1 |
| 114774 | Pawr | PRKC, apoptosis, WT1, regulator | Mus musculus | Pro-Longevity |
|
Pawr |
| 18534 | Pck1 | phosphoenolpyruvate carboxykinase 1, cytosolic | Mus musculus | Pro-Longevity |
|
Pck1 |
| 18627 | Per2 | period circadian clock 2 | Mus musculus | Anti-Longevity |
|
Per2 |
| 18792 | Plau | Plasminogen activator, urokinase | Mus musculus | Pro-Longevity |
20% |
Plau |
| 18975 | Polg | Polymerase (DNA directed), gamma | Mus musculus | Pro-Longevity |
|
Polg |
| 18736 | Pou1f1 | POU domain, class 1, transcription factor 1 | Mus musculus | Anti-Longevity |
40% |
Pou1f1 |
| 19016 | Pparg | Peroxisome proliferator activated receptor gamma | Mus musculus | Pro-Longevity |
|
Pparg |
| 53892 | Ppm1d | protein phosphatase 1D magnesium-dependent, delta isoform | Mus musculus | Pro-Longevity |
|
Ppm1d |
| 18477 | Prdx1 | Peroxiredoxin 1 | Mus musculus | Pro-Longevity |
|
Prdx1 |
| 19088 | Prkar2b | protein kinase, cAMP dependent regulatory, type II beta | Mus musculus | Anti-Longevity |
14% |
Prkar2b |
| 19127 | Prop1 | Prophet of Pit1, paired-like homeodomain transcription factor | Mus musculus | Anti-Longevity |
|
Prop1 |
| 19211 | Pten | Phosphatase and tensin homolog | Mus musculus | Pro-Longevity |
|
Pten |
| 66679 | Rae1 | RAE1 RNA export 1 homolog (S. pombe) | Mus musculus | Pro-Longevity |
|
Rae1 |
| 56190 | Rbm38 | RNA binding motif protein 38 | Mus musculus | Pro-Longevity |
22% |
Rbm38 |
| 78757 | Rictor | RPTOR independent companion of MTOR, complex 2 | Mus musculus | Pro-Longevity |
40% |
Rictor |
| 72508 | Rps6kb1 | ribosomal protein S6 kinase, polypeptide 1 | Mus musculus | Anti-Longevity |
19% |
Rps6kb1 |
| 18787 | Serpine1 | serine (or cysteine) peptidase inhibitor, clade E, member 1 | Mus musculus | Anti-Longevity |
|
Serpine1 |
| 20416 | Shc1 | SHC (Src homology 2 domain containing) transforming protein 1 | Mus musculus | Anti-Longevity |
30% |
Shc1 |
| 83382 | Siglece | sialic acid binding Ig-like lectin E | Mus musculus | Pro-Longevity |
17% |
Siglece |
| 93759 | Sirt1 | Sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae) | Mus musculus | Pro-Longevity |
|
Sirt1 |
| 50721 | Sirt6 | sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae) | Mus musculus | Pro-Longevity |
|
Sirt6 |
| 209011 | Sirt7 | Sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae) | Mus musculus | Pro-Longevity |
59% |
Sirt7 |
| 55961 | Slc13a1 | Solute carrier family 13 (sodium/sulfate symporters), member 1 | Mus musculus | Anti-Longevity |
25% |
Slc13a1 |
| 11739 | Slc25a4 | solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 | Mus musculus | Pro-Longevity |
|
Slc25a4 |
| 216233 | Socs2 | Suppressor of cytokine signaling 2 | Mus musculus | Pro-Longevity |
35% |
Socs2 |
| 20656 | Sod2 | Superoxide dismutase 2, mitochondrial | Mus musculus | Pro-Longevity |
43% |
Sod2 |
| 6649 | SOD3 | superoxide dismutase 3 | Mus musculus | Pro-Longevity |
|
SOD3 |
| 18412 | Sqstm1 | sequestosome 1 | Mus musculus | Pro-Longevity |
34% |
Sqstm1 |
| 56424 | Stub1 | STIP1 homology and U-Box containing protein 1 | Mus musculus | Pro-Longevity |
|
Stub1 |
| 20930 | Surf1 | surfeit gene 1 | Mus musculus | Anti-Longevity |
20% |
Surf1 |
| 21750 | Terf2 | telomeric repeat binding factor 2 | Mus musculus | Anti-Longevity |
|
Terf2 |
| 21752 | Tert | Telomerase reverse transcriptase | Mus musculus | Pro-Longevity |
|
Tert |
| 21976 | Top3b | Topoisomerase (DNA) III beta | Mus musculus | Pro-Longevity |
|
Top3b |
| 106021 | Topors | Topoisomerase I binding, arginine/serine-rich | Mus musculus | Pro-Longevity |
42% |
Topors |
| 22019 | Tpp2 | Tripeptidyl peptidase II | Mus musculus | Pro-Longevity |
|
Tpp2 |
| 22059 | Trp53 | Transformation related protein 53 | Mus musculus | Pro-Longevity |
23% |
Trp53 |
| 27223 | Trp53bp1 | Transformation related protein 53 binding protein 1 | Mus musculus | Anti-Longevity |
|
Trp53bp1 |
| 22061 | Trp63 | Transformation related protein 63 | Mus musculus | Pro-Longevity |
70% |
Trp63 |
| 22062 | Trp73 | transformation related protein 73 | Mus musculus | Pro-Longevity |
31% |
Trp73 |
| 193034 | Trpv1 | transient receptor potential cation channel, subfamily V, member 1 | Mus musculus | Anti-Longevity |
16% |
Trpv1 |
| 22166 | Txn1 | Thioredoxin 1 | Mus musculus | Pro-Longevity |
35% |
Txn1 |
| 24108 | Ubd | ubiquitin D | Mus musculus | Anti-Longevity |
20% |
Ubd |
| 22228 | Ucp2 | uncoupling protein 2 (mitochondrial, proton carrier) | Mus musculus | Pro-Longevity |
20% |
Ucp2 |
| 22590 | Xpa | Xeroderma pigmentosum, complementation group A | Mus musculus | Pro-Longevity |
|
Xpa |
| 22596 | Xrcc5 | X-ray repair complementing defective repair in Chinese hamster cells 5 | Mus musculus | Pro-Longevity |
40% |
Xrcc5 |
| 14375 | Xrcc6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | Mus musculus | Pro-Longevity |
|
Xrcc6 |
| 230709 | Zmpste24 | zinc metallopeptidase, STE24 homolog (S. cerevisiae) | Mus musculus | Pro-Longevity |
|
Zmpste24 |