GenAge entry for Mgat5 (Mus musculus)
Gene information (ID: 436)
- Symbol
- Mgat5
- Aliases
- AI480971; GlcNAc-TV; 4930471A21Rik; 5330407H02Rik
- Name
- mannoside acetylglucosaminyltransferase 5
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- Mannoside acetylglucosaminyltransferase 5
Potential relevance to longevity and/or ageing
- Observations
- Although grossly normal at birth, knockout mice display multiple deficiencies with age including hypersensitivity to autoimmune disease, higher oxidative metabolism, resistance to weight-gain, and signs of early ageing such as osteoporosis, decreased muscle mass, and depletion of adult stem cells. Interestingly, Mgat5-/-Pten+/- and Mgat5+/-Pten+/- mutant mice showed a small but significant increase in lifespan when compared to Pten+/- mice, accompanied by an apparent delay in the inevitable development of cancer in Pten+/- mice.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Knockout
- Longevity Category
- Pro-Longevity
- Primary reference
-
Homologs in other organisms
External links
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (107895)
- Homologues
- Search HomoloGene
- UniProt
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- Internet
- Search Google or Search Google Scholar