GenAge entry for Htra2 (Mus musculus)
Gene information (ID: 1802)
- Symbol
- Htra2
- Aliases
- Omi; mnd2; Prss25; AI481710
- Name
- HtrA serine peptidase 2
- Organism
- Mus musculus (AnAge)
Potential relevance to longevity and/or ageing
- Observations
- Mice with both a mutation in Htra2 (which normally causes neurodegeneration 30-40 days after birth) and expressing human HTRA2 in the central nervous system (which rescues mice from neurodegeneration and prevents premature death) develop signs of premature ageing. These include premature weight loss, hair loss, reduced fertility and kyphosis.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutation
- Longevity Category
- Pro-Longevity
- Primary reference
-
In other databases
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as HTRA2
Homologs in other organisms
- Danio rerio
- zgc:174193
- Danio rerio
- si:dkey-112g5.13
- Danio rerio
- si:dkey-10b15.8
- Danio rerio
- zgc:174193
- Danio rerio
- si:dkey-84o3.7
- Danio rerio
- si:dkey-112g5.14
- Danio rerio
- si:dkey-112g5.16
- Danio rerio
- zgc:173425
- Danio rerio
- si:dkey-112g5.13
- Danio rerio
- si:dkey-33c12.12
- Danio rerio
- si:dkey-84o3.7
- Danio rerio
- si:dkey-84o3.6
- Danio rerio
- si:dkey-84o3.3
- Danio rerio
- si:dkey-112g5.12
- Danio rerio
- si:dkey-112g5.11
- Danio rerio
- HTRA2
- Danio rerio
- BX469935.1
- Danio rerio
- si:dkey-19p15.4
- Danio rerio
- si:dkey-265c15.6
- Danio rerio
- si:dkey-33c12.14
- Danio rerio
- si:dkey-33c12.12
- Danio rerio
- si:dkey-33c12.11
- Danio rerio
- si:dkey-33c12.10
- Danio rerio
- si:dkey-112g5.14
- Drosophila melanogaster
- HtrA2
- Homo sapiens
- HTRA2
- Rattus norvegicus
- Htra2
External links
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (64704)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar