LongevityMap variant

Entry Details

Longevity Association
Non-significant
Population
German
Study Design
19 SNPs were examined in 1612 long-lived individuals (centenarians and nonagenarians) and 1104 younger controls as well as a subgroup of 748 centenarians from 1612 LLIs and 1104 younger controls.
Conclusions
No association was detected between the tested SNPs and the longevity phenotype, in the entire long-lived sample set nor in the centenarian subgroup analysis. There was no considerable influence of sequence variation in the SOD genes on human longevity in Germans.
Identifier
rs4880
In Other Studies (IDs)
364 2655
Cytogenetic Location
6q25.3
UCSC Genome Browser
View 6q25.3 on the UCSC genome browser

Gene details

HGNC symbol
SOD2
Aliases
IPOB; IPO-B; MNSOD; MVCD6; Mn-SOD 
Common name
superoxide dismutase 2 
Description
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]
Other longevity studies of this gene
21
OMIM
147460
Ensembl
ENSG00000112096
UniProt/Swiss-Prot
A0A0C4DFU1_HUMAN
Entrez Gene
6648
UniGene
487046
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
sod-2
Caenorhabditis elegans
sod-3
Danio rerio
sod2
Drosophila melanogaster
Sod2
Mus musculus
Sod2
Rattus norvegicus
Sod2
Saccharomyces cerevisiae
SOD2
Schizosaccharomyces pombe
SPBC16A3.14

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as SOD2
  • A homolog of this gene for Drosophila melanogaster is present as Sod2
  • A homolog of this gene for Mus musculus is present as Sod2
  • A homolog of this gene for Caenorhabditis elegans is present as sod-2
GenAge human genes
  • This gene is present as SOD2
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as SOD2
CellAge
  • This gene is present as SOD2

References

Gentschew et al. (2013)

Other variants which are also part of this study