GenAge entry for XRCC5 (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 112)
- HGNC symbol
- XRCC5
- Aliases
- KU80; KARP-1; Ku86; KUB2
- Common name
- X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
XRCC5, or Ku80, is a helicase involved in DNA repair and chromatin remodelling [577]. It has been found associated with the telomeres [158] and with WRN [983]. XRCC5-null mice live about 38 weeks and appear to age prematurely [1490]. As such, XRCC5 may play a role in human ageing.
Cytogenetic information
- Cytogenetic band
- 2q35
- Location
- 216,109,297 bp to 216,206,293 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000723; telomere maintenance
GO:0006302; double-strand break repair
GO:0006303; double-strand break repair via nonhomologous end joining
GO:0006310; DNA recombination
GO:0006351; transcription, DNA-templated
GO:0007420; brain development
GO:0008283; cell proliferation
GO:0032481; positive regulation of type I interferon production
GO:0032508; DNA duplex unwinding
GO:0042493; response to drug
GO:0045892; negative regulation of transcription, DNA-templated
And 10 more GO terms Cellular component: GO:0000783; nuclear telomere cap complex
GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0016020; membrane
GO:0043564; Ku70:Ku80 complex
GO:0070419; nonhomologous end joining complex
Function: GO:0003677; DNA binding
GO:0003684; damaged DNA binding
GO:0003690; double-stranded DNA binding
GO:0003691; double-stranded telomeric DNA binding
GO:0004003; ATP-dependent DNA helicase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0031625; ubiquitin protein ligase binding
GO:0042162; telomeric DNA binding
GO:0044212; transcription regulatory region DNA binding
And 4 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TERT, ATM, WRN, MYC, EGFR, NBN, PARP1, BRCA1, RPA1, TOP2A, TOP1, UBE2I, CEBPA, TERF1, PRKDC, AR, XRCC5, PCNA, TERF2, XRCC6, BAX, HSF1, BMI1, TFAP2A, APEX1, POLA1, H2AFX, HOXB7, HOXC4, ESR1, ATR, SIRT6, PPARG, SIRT7, TP53BP1
- STRING interaction network
Retrieve sequences for XRCC5
Homologs in model organisms
- Danio rerio
- xrcc5
- Drosophila melanogaster
- Ku80
- Mus musculus
- Xrcc5
- Rattus norvegicus
- Xrcc5
- Schizosaccharomyces pombe
- pku80
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Xrcc5
- LongevityMap
- This gene is present as XRCC5
Selected references
External links
- EPD
- ORF Accession
- NM_021141
- CDS Accession
- NP_066964
- OMIM
- 194364
- HPRD
- 08935
- Ensembl
- XRCC5
- UniProt/Swiss-Prot
- XRCC5_HUMAN
- GeneCards
- XRCC5
- Entrez Gene
- 7520
- GenAtlas
- XRCC5
- Internet
- Search Google