GenAge entry for TERF1 (Homo sapiens)
Gene name (HAGRID: 105)
- HGNC symbol
- TERF1
- Aliases
- PIN2; TRF1; TRF; TRBF1
- Common name
- telomeric repeat binding factor (NIMA-interacting) 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
TERF1 associates with the telomeres and appears to be an important regulator of telomere biology [73]. Expression of TERF1 in mice prevented age-related decline in neuromuscular function, glucose homeostasis, cognitive function, lipid stores, and chronic anemia [4503]. Though, its role in human ageing is unknown, TERF1 levels decrease with ageing in both mice and humans.
Cytogenetic information
- Cytogenetic band
- 8q21.11
- Location
- 73,008,862 bp to 73,047,752 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000723; telomere maintenance
GO:0007004; telomere maintenance via telomerase
GO:0007067; mitotic nuclear division
GO:0008156; negative regulation of DNA replication
GO:0016233; telomere capping
GO:0031627; telomeric loop formation
GO:0032211; negative regulation of telomere maintenance via telomerase
GO:0032214; negative regulation of telomere maintenance via semi-conservative replication
GO:0042493; response to drug
GO:0045141; meiotic telomere clustering
GO:0051301; cell division
And 6 more GO terms Cellular component: GO:0000783; nuclear telomere cap complex
GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005819; spindle
GO:0070187; telosome
Function: GO:0003677; DNA binding
GO:0003691; double-stranded telomeric DNA binding
GO:0003720; telomerase activity
GO:0005515; protein binding
GO:0008301; DNA binding, bending
GO:0042162; telomeric DNA binding
GO:0042803; protein homodimerization activity
GO:0043130; ubiquitin binding
GO:0098505; G-rich strand telomeric DNA binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TERT, ATM, NBN, BRCA1, BLM, HSP90AA1, ABL1, EP300, TERF1, PRKDC, XRCC5, FEN1, TERF2, RECQL4, FOXM1, SNCG, PRDX1, GSS, PCMT1, APEX1, MTOR, DBN1, STUB1
- STRING interaction network
Retrieve sequences for TERF1
Homologs in model organisms
In other databases
- LongevityMap
- This gene is present as TERF1
Selected references
External links
- EPD
- ORF Accession
- NM_017489
- CDS Accession
- NP_059523
- OMIM
- 600951
- HPRD
- 02975
- Ensembl
- TERF1
- UniProt/Swiss-Prot
- TERF1_HUMAN
- GeneCards
- TERF1
- Entrez Gene
- 7013
- GenAtlas
- TERF1
- Internet
- Search Google