LongevityMap Gene
Gene details
- HGNC symbol
- TERF1
- Aliases
- TRF; PIN2; TRF1; TRBF1; t-TRF1; hTRF1-AS
- Common name
- telomeric repeat binding factor 1
- Description
- This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 8q21.11
- UCSC Genome Browser
- View 8q21.11 on the UCSC genome browser
- OMIM
- 600951
- Ensembl
- ENSG00000147601
- UniProt/Swiss-Prot
- TERF1_HUMAN
- Entrez Gene
- 7013
- UniGene
- 442707
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- GenAge human genes
- This gene is present as TERF1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs10098931
- Reference