GenAge entry for DBN1 (Homo sapiens)

Gene name (HAGRID: 228)

HGNC symbol
DBN1 
Aliases
D0S117E 
Common name
drebrin 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

DBN1 is thought to be involved in neuronal growth. In a mouse model of Alzheimer's disease, DBN1 levels were found to decline with age [1666]. DBN1 could thus play a role and neurodegenerative diseases.

Cytogenetic information

Cytogenetic band
5q35.3
Location
177,456,613 bp to 177,473,693 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0007015; actin filament organization
GO:0010643; cell communication by chemical coupling
GO:0010644; cell communication by electrical coupling
GO:0032507; maintenance of protein location in cell
GO:0048168; regulation of neuronal synaptic plasticity
GO:0050773; regulation of dendrite development
GO:0061351; neural precursor cell proliferation
GO:0098609; cell-cell adhesion
Cellular component: GO:0005737; cytoplasm
GO:0005886; plasma membrane
GO:0005913; cell-cell adherens junction
GO:0005921; gap junction
GO:0005938; cell cortex
GO:0015629; actin cytoskeleton
GO:0030425; dendrite
GO:0030426; growth cone
GO:0042641; actomyosin
Function: GO:0003779; actin binding
GO:0005515; protein binding
GO:0005522; profilin binding
GO:0098641; cadherin binding involved in cell-cell adhesion
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, PTEN, TERF1, GRB2, SP1, BMI1, ESR1, PPP1CA, CDC42, BAK1
STRING interaction network
Protein-Protein network diagram for DBN1

Retrieve sequences for DBN1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
dbn1
Mus musculus
Dbn1
Rattus norvegicus
Dbn1
Schizosaccharomyces pombe
app1

Selected references

External links

EPD
ORF Accession
NM_004395
CDS Accession
NP_004386
OMIM
126660
HPRD
00545
Ensembl
DBN1
UniProt/Swiss-Prot
DREB_HUMAN
GeneCards
DBN1
Entrez Gene
1627
GenAtlas
DBN1
Internet
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