GenAge entry for RPA1 (Homo sapiens)
Gene name (HAGRID: 67)
- HGNC symbol
- RPA1
- Aliases
- REPA1; RPA70; HSSB; RF-A; RP-A
- Common name
- replication protein A1, 70kDa
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
- Description
RPA1 is involved in replication, recombination, and DNA repair. Due to its involvement with ageing-related genes, such as WRN [441], RPA1 has been hinted as a player in the ageing process. Nonetheless, there is no direct evidence that RPA1 is linked to human ageing.
Cytogenetic information
- Cytogenetic band
- 17p13.3
- Location
- 1,829,979 bp to 1,899,554 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000082; G1/S transition of mitotic cell cycle
GO:0000722; telomere maintenance via recombination
GO:0000723; telomere maintenance
GO:0000724; double-strand break repair via homologous recombination
GO:0006260; DNA replication
GO:0006261; DNA-dependent DNA replication
GO:0006281; DNA repair
GO:0006283; transcription-coupled nucleotide-excision repair
GO:0006284; base-excision repair
GO:0006289; nucleotide-excision repair
GO:0006293; nucleotide-excision repair, preincision complex stabilization
And 16 more GO terms Cellular component: GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005662; DNA replication factor A complex
GO:0016605; PML body
Function: GO:0003684; damaged DNA binding
GO:0003697; single-stranded DNA binding
GO:0005515; protein binding
GO:0046872; metal ion binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, ATM, WRN, LMNA, EGFR, NBN, PARP1, BRCA1, RPA1, BLM, BRCA2, TOP2A, TOP2B, RAD51, ERCC6, PRKDC, XRCC5, PCNA, TERF2, XRCC6, POLD1, XPA, PRDX1, RAD52, TOP3B, CCNA2, LMNB1, EEF1A1, APEX1, HSPA8, CDK1, POLA1, ATR, BUB3, TP53BP1, CDK7, SPRTN
- STRING interaction network
Retrieve sequences for RPA1
Homologs in model organisms
- Caenorhabditis elegans
- rpa-1
- Danio rerio
- rpa1
- Drosophila melanogaster
- RpA-70
- Mus musculus
- Rpa1
- Rattus norvegicus
- Rpa1
- Saccharomyces cerevisiae
- RFA1
- Schizosaccharomyces pombe
- ssb1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as rpa-1
- LongevityMap
- This gene is present as RPA1
Selected references
External links
- EPD
- ORF Accession
- NM_002945
- CDS Accession
- NP_002936
- OMIM
- 179835
- HPRD
- 01565
- Ensembl
- RPA1
- UniProt/Swiss-Prot
- RFA1_HUMAN
- GeneCards
- RPA1
- Entrez Gene
- 6117
- GenAtlas
- RPA1
- Internet
- Search Google