GenAge entry for RPA1 (Homo sapiens)

Gene name (HAGRID: 67)

HGNC symbol
RPA1 
Aliases
REPA1; RPA70; HSSB; RF-A; RP-A 
Common name
replication protein A1, 70kDa 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

RPA1 is involved in replication, recombination, and DNA repair. Due to its involvement with ageing-related genes, such as WRN [441], RPA1 has been hinted as a player in the ageing process. Nonetheless, there is no direct evidence that RPA1 is linked to human ageing.

Cytogenetic information

Cytogenetic band
17p13.3
Location
1,829,979 bp to 1,899,554 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000082; G1/S transition of mitotic cell cycle
GO:0000722; telomere maintenance via recombination
GO:0000723; telomere maintenance
GO:0000724; double-strand break repair via homologous recombination
GO:0006260; DNA replication
GO:0006261; DNA-dependent DNA replication
GO:0006281; DNA repair
GO:0006283; transcription-coupled nucleotide-excision repair
GO:0006284; base-excision repair
GO:0006289; nucleotide-excision repair
GO:0006293; nucleotide-excision repair, preincision complex stabilization
And 16 more GO terms
Cellular component: GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005662; DNA replication factor A complex
GO:0016605; PML body
Function: GO:0003684; damaged DNA binding
GO:0003697; single-stranded DNA binding
GO:0005515; protein binding
GO:0046872; metal ion binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, ATM, WRN, LMNA, EGFR, NBN, PARP1, BRCA1, RPA1, BLM, BRCA2, TOP2A, TOP2B, RAD51, ERCC6, PRKDC, XRCC5, PCNA, TERF2, XRCC6, POLD1, XPA, PRDX1, RAD52, TOP3B, CCNA2, LMNB1, EEF1A1, APEX1, HSPA8, CDK1, POLA1, ATR, BUB3, TP53BP1, CDK7, SPRTN
STRING interaction network
Protein-Protein network diagram for RPA1

Retrieve sequences for RPA1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
rpa-1
Danio rerio
rpa1
Drosophila melanogaster
RpA-70
Mus musculus
Rpa1
Rattus norvegicus
Rpa1
Saccharomyces cerevisiae
RFA1
Schizosaccharomyces pombe
ssb1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as rpa-1
LongevityMap
  • This gene is present as RPA1

Selected references

External links

EPD
ORF Accession
NM_002945
CDS Accession
NP_002936
OMIM
179835
HPRD
01565
Ensembl
RPA1
UniProt/Swiss-Prot
RFA1_HUMAN
GeneCards
RPA1
Entrez Gene
6117
GenAtlas
RPA1
Internet
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