GenAge entry for RAD51 (Homo sapiens)
Gene name (HAGRID: 84)
- HGNC symbol
- RAD51
- Aliases
- HsRad51; HsT16930; BRCC5; FANCR; RAD51A; RECA
- Common name
- RAD51 recombinase
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
- Description
Involved in DNA unwinding and repair [489], RAD51 has been reported to be an important player in the cellular senescence of yeast [192]. Disruption of RAD51 in mice results in embryonic lethality [488]. Its role in mammalian ageing remains unknown.
Cytogenetic information
- Cytogenetic band
- 15q15.1
- Location
- 40,695,129 bp to 40,732,158 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000722; telomere maintenance via recombination
GO:0000724; double-strand break repair via homologous recombination
GO:0000730; DNA recombinase assembly
GO:0000731; DNA synthesis involved in DNA repair
GO:0000732; strand displacement
GO:0001932; regulation of protein phosphorylation
GO:0006268; DNA unwinding involved in DNA replication
GO:0006281; DNA repair
GO:0006310; DNA recombination
GO:0006312; mitotic recombination
GO:0006974; cellular response to DNA damage stimulus
And 22 more GO terms Cellular component: GO:0000228; nuclear chromosome
GO:0000784; nuclear chromosome, telomeric region
GO:0000785; chromatin
GO:0000790; nuclear chromatin
GO:0000793; condensed chromosome
GO:0000794; condensed nuclear chromosome
GO:0000800; lateral element
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
And 7 more GO terms Function: GO:0000150; recombinase activity
GO:0000400; four-way junction DNA binding
GO:0003682; chromatin binding
GO:0003690; double-stranded DNA binding
GO:0003697; single-stranded DNA binding
GO:0004520; endodeoxyribonuclease activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0042802; identical protein binding
GO:0043142; single-stranded DNA-dependent ATPase activity
And 2 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, ATM, WRN, BRCA1, RPA1, BLM, HSP90AA1, ABL1, BRCA2, RAD51, UBE2I, PML, PCNA, RAD52, SP1, SUMO1, H2AFX, ESR1, CDC42
- STRING interaction network
Retrieve sequences for RAD51
Homologs in model organisms
- Danio rerio
- rad51
- Drosophila melanogaster
- spn-A
- Mus musculus
- Rad51
- Rattus norvegicus
- Rad51
- Saccharomyces cerevisiae
- RAD51
- Schizosaccharomyces pombe
- rhp51
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as RAD51
- LongevityMap
- This gene is present as RAD51
- CellAge gene expression
- This gene is present as RAD51