Saccharomyces cerevisiaeGenAge entry for SNF1 (Saccharomyces cerevisiae)

Gene information (ID: 619)

Symbol
SNF1
Aliases
CAT1; CCR1; GLC2; HAF3; PAS14
Name
AMP-activated serine/threonine protein kinase
Organism
Saccharomyces cerevisiae (AnAge)

Potential relevance to longevity and/or ageing

Observations
Overexpression shortened lifespan accompanied by signs of premature ageing.
Lifespan Effect
Decrease
Genetic Manipulation
Overexpression
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Replicative lifespan increased by 50% in the alpha strain
    % change in avg or median lifespan
    Replicative lifespan is 50% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Deletion
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      Reduced chronological lifespan
      Lifespan Effect
      Decrease
      Genetic Manipulation
      Overexpression
      Longevity Category
      Anti-Longevity
      Primary reference
        Observations
        Mean chronological lifespan decreased in the a strain
        Lifespan Effect
        Decrease
        Genetic Manipulation
        Deletion
        Longevity Category
        Necessary for fitness
        Primary reference

          In other databases

          GenAge model organism genes
          • A homolog of this gene for Caenorhabditis elegans is present as aak-2
          • A homolog of this gene for Drosophila melanogaster is present as SNF1A
          GenDR gene manipulations
          • A homolog of this gene for Caenorhabditis elegans is present as aak-2
          LongevityMap
          • A homolog of this gene for Homo sapiens is present as PRKAA1
          CellAge
          • A homolog of this gene for Homo sapiens is present as NUAK1
          • A homolog of this gene for Homo sapiens is present as NUAK2
          • A homolog of this gene for Homo sapiens is present as PRKAA2
          • A homolog of this gene for Homo sapiens is present as SIK1
          CellAge gene expression
          • A homolog of this gene for Homo sapiens is present as NUAK1

          Homologs in other organisms

          Caenorhabditis elegans
          par-1
          Caenorhabditis elegans
          kin-29
          Caenorhabditis elegans
          aak-2
          Caenorhabditis elegans
          unc-82
          Caenorhabditis elegans
          aak-1
          Danio rerio
          MARK4 (1 of many)
          Danio rerio
          nuak1b
          Danio rerio
          prkaa1
          Danio rerio
          mark3b
          Danio rerio
          mark4a
          Danio rerio
          sik2b
          Danio rerio
          zgc:66101
          Danio rerio
          mark3a
          Danio rerio
          sik1
          Danio rerio
          nuak2
          Danio rerio
          si:ch211-117c9.1
          Danio rerio
          prkaa2
          Danio rerio
          mark2a
          Danio rerio
          nuak1a
          Danio rerio
          MARK1
          Danio rerio
          sik2a
          Danio rerio
          mark2b
          Drosophila melanogaster
          KP78a
          Drosophila melanogaster
          KP78b
          Drosophila melanogaster
          CG43143
          Drosophila melanogaster
          Sik2
          Drosophila melanogaster
          AMPKalpha
          Drosophila melanogaster
          Sik3
          Drosophila melanogaster
          par-1
          Homo sapiens
          PRKAA1
          Homo sapiens
          PRKAA2
          Homo sapiens
          NUAK1
          Homo sapiens
          SIK2
          Homo sapiens
          SIK3
          Homo sapiens
          MARK3
          Homo sapiens
          MARK1
          Homo sapiens
          102724428
          Homo sapiens
          SIK1
          Homo sapiens
          MARK4
          Homo sapiens
          NUAK2
          Homo sapiens
          MARK2
          Mus musculus
          Mark2
          Mus musculus
          Mark3
          Mus musculus
          Sik2
          Mus musculus
          Sik3
          Mus musculus
          Nuak1
          Mus musculus
          Prkaa1
          Mus musculus
          Mark1
          Mus musculus
          Mark4
          Mus musculus
          Nuak2
          Mus musculus
          Prkaa2
          Mus musculus
          Sik1
          Rattus norvegicus
          Mark3
          Rattus norvegicus
          Prkaa2
          Rattus norvegicus
          Prkaa1
          Rattus norvegicus
          Mark2
          Rattus norvegicus
          Sik1
          Rattus norvegicus
          Mark1
          Rattus norvegicus
          Sik2
          Rattus norvegicus
          Sik3
          Rattus norvegicus
          Mark4
          Rattus norvegicus
          Nuak1
          Rattus norvegicus
          Nuak2
          Schizosaccharomyces pombe
          ssp2

          External links

          Saccharomyces Genome Database
          Search
          Ensembl
          Search
          Entrez Gene
          View on Entrez Gene database (852088)
          Homologues
          Search HomoloGene
          UniProt
          Search
          Internet
          Search Google or Search Google Scholar