LongevityMap Gene
Gene details
- HGNC symbol
- PRKAA1
- Aliases
- AMPK; AMPKa1
- Common name
- protein kinase AMP-activated catalytic subunit alpha 1
- Description
- The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 5p13.1
- UCSC Genome Browser
- View 5p13.1 on the UCSC genome browser
- OMIM
- 602739
- Ensembl
- ENSG00000132356
- UniProt/Swiss-Prot
- AAPK1_HUMAN
- Entrez Gene
- 5562
- UniGene
- 43322
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- aak-2
- Caenorhabditis elegans
- aak-1
- Danio rerio
- prkaa1
- Drosophila melanogaster
- AMPKalpha
- Mus musculus
- Prkaa1
- Rattus norvegicus
- Prkaa1
- Saccharomyces cerevisiae
- SNF1
In other databases
- GenAge model organism genes
- GenDR gene manipulations
- A homolog of this gene for Caenorhabditis elegans is present as aak-2
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs12517210
- Reference