Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: aak-2

Gene Information (Entrez Gene ID: 181727)

Symbol
aak-2
Name
AMP-Activated Kinase 2
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
181727

Potential relevance to dietary restriction and ageing

Observations

AAK-2 could be a sensor that couples energy levels and insulin-like signals to lifespan. aak-2(ok524) knockout mutants have a 12% and 18% shorter mean and maximum lifespan, respectively as well as faster age-dependent accumulation of a lipofuscin-like fluorescent pigment in the intestine [2232]. Solid DR increases AMP:ATP ratio. aak-2 mutation suppresses lifespan extension and delay of the decline in locomotor activity resulting from solid DR. A constitutive active mutation of aak-2 is sufficient to cause increase stress resistance as well as to significantly extend lifespan. Both increased stress resistance and extended lifespan is reverted in daf-16 knockdown by RNAi [2564]. aak-2 mutation cancels out the lifespan extension effect of solid DR and peptone dilution, regardless of the concentration of bacteria or peptones. Bacterial dilution DR significantly extends lifespan of aak-2 mutants, but to a lesser extent than that of wild-type. eat-2 mutation extends the lifespan of aak-2 mutants to the same extent than that of wild-type.

References

    In other databases

    GenAge model organism genes
    • This gene is present as aak-2
    • A homolog of this gene for Saccharomyces cerevisiae is present as SNF1
    • A homolog of this gene for Drosophila melanogaster is present as SNF1A
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as PRKAA1
    CellAge
    • A homolog of this gene for Homo sapiens is present as PRKAA2

    Homologs

    Danio rerio
    prkaa2
    Danio rerio
    prkaa1
    Drosophila melanogaster
    AMPKalpha
    Homo sapiens
    PRKAA1
    Homo sapiens
    PRKAA2
    Mus musculus
    Prkaa2
    Mus musculus
    Prkaa1
    Rattus norvegicus
    Prkaa2
    Rattus norvegicus
    Prkaa1
    Saccharomyces cerevisiae
    SNF1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    ID 181727
    Homologues
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    UniProt
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    Internet
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