Cell Senescence Entries for SIK1
- Cell Types
- Embryonic kidney, Lung fibroblast
- Cell Lines
- HEK293T, IMR-90, MRC-5
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)
SIK1 Gene Information
- HGNC symbol
- SIK1
- Aliases
- msk; SNF1LK
- Common name
- salt inducible kinase 1
- Entrez Id
- 150094
- Description
- This gene encodes a serine/threonine protein kinase that contains a ubiquitin-associated (UBA) domain. The encoded protein is a member of the adenosine monophosphate-activated kinase (AMPK) subfamily of kinases that play a role in conserved signal transduction pathways. A mutation in this gene is associated with early infantile epileptic encephalopathy 30. [provided by RefSeq, Nov 2016].
SIK1 Ontologies
- Gene Ontology
-
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:35556; intracellular signal transduction
GO:30154; cell differentiation
GO:48511; rhythmic process
GO:46777; protein autophosphorylation
GO:42149; cellular response to glucose starvation
GO:2028; regulation of sodium ion transport
GO:45721; negative regulation of gluconeogenesis
GO:7346; regulation of mitotic cell cycle
And 8 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
Show all GO termsFunction: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:287; magnesium ion binding
GO:5515; protein binding
And 4 more GO terms
Homologs of SIK1 in Model Organisms
- Caenorhabditis elegans
- kin-29
- Danio rerio
- sik1
- Drosophila melanogaster
- Sik2
- Mus musculus
- Sik1
- Rattus norvegicus
- Sik1
- Saccharomyces cerevisiae
- SNF1
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as SNF1
External links
- OMIM
- 605705
- Ensembl
- ENSG00000142178
- Entrez Gene
- 150094
- UniGene
- 700423
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SIK1
- GeneCards
- SIK1