Saccharomyces cerevisiaeGenAge entry for RAS2 (Saccharomyces cerevisiae)

Gene information (ID: 540)

Symbol
RAS2
Aliases
CTN5; CYR3; GLC5; TSL7
Name
GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous gr
Organism
Saccharomyces cerevisiae (AnAge)

Potential relevance to longevity and/or ageing

Observations
Overexpression of a mutant gene caused a 43% increase in mean and 18% increase in maximum lifespan.
% change in max lifespan
Maximum lifespan is 18% higher.
% change in avg or median lifespan
Average lifespan is 43% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Deletion of the RAS2 gene, which functions upstream of CYR1, doubles the mean life span by a mechanism that requires Msn2/4 and Sod2
    Lifespan Effect
    Increase
    Genetic Manipulation
    Deletion
    Longevity Category
    Anti-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Caenorhabditis elegans is present as let-60
      • A homolog of this gene for Caenorhabditis elegans is present as ral-1
      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as HRAS
      GenAge microarray genes
      • A homolog of this gene for Homo sapiens is present as RRAS
      LongevityMap
      • A homolog of this gene for Homo sapiens is present as HRAS
      • A homolog of this gene for Homo sapiens is present as REM2
      CellAge
      • A homolog of this gene for Homo sapiens is present as HRAS
      • A homolog of this gene for Homo sapiens is present as NRAS
      • A homolog of this gene for Homo sapiens is present as RRAD
      • A homolog of this gene for Homo sapiens is present as RRAS2
      CellAge gene expression
      • A homolog of this gene for Homo sapiens is present as GEM
      • A homolog of this gene for Homo sapiens is present as NRAS
      • A homolog of this gene for Homo sapiens is present as RRAS
      • A homolog of this gene for Homo sapiens is present as MRAS

      Homologs in other organisms

      Caenorhabditis elegans
      ral-1
      Caenorhabditis elegans
      Y52B11A.4
      Caenorhabditis elegans
      ras-2
      Caenorhabditis elegans
      ras-1
      Caenorhabditis elegans
      let-60
      Danio rerio
      ralba
      Danio rerio
      ralba
      Danio rerio
      kras
      Danio rerio
      rras
      Danio rerio
      rem1
      Danio rerio
      hrasa
      Danio rerio
      rrad
      Danio rerio
      mras
      Danio rerio
      nras
      Danio rerio
      rras2
      Danio rerio
      zgc:55558
      Danio rerio
      ralaa
      Danio rerio
      ralab
      Danio rerio
      rem2
      Danio rerio
      kras
      Danio rerio
      gem
      Danio rerio
      MRAS (1 of many)
      Danio rerio
      hrasb
      Drosophila melanogaster
      Ras85D
      Drosophila melanogaster
      Rgk1
      Drosophila melanogaster
      Ras64B
      Drosophila melanogaster
      Rgk3
      Drosophila melanogaster
      Rgk2
      Drosophila melanogaster
      Rala
      Drosophila melanogaster
      CG42541
      Homo sapiens
      NRAS
      Homo sapiens
      RALA
      Homo sapiens
      ERAS
      Homo sapiens
      GEM
      Homo sapiens
      HRAS
      Homo sapiens
      REM2
      Homo sapiens
      KRAS
      Homo sapiens
      RRAD
      Homo sapiens
      MRAS
      Homo sapiens
      RRAS2
      Homo sapiens
      REM1
      Homo sapiens
      RALB
      Homo sapiens
      RRAS
      Mus musculus
      Eras
      Mus musculus
      Rem2
      Mus musculus
      Rem1
      Mus musculus
      Rras
      Mus musculus
      Rala
      Mus musculus
      Rrad
      Mus musculus
      Nras
      Mus musculus
      Mras
      Mus musculus
      Gem
      Mus musculus
      Hras
      Mus musculus
      Kras
      Mus musculus
      Rras2
      Mus musculus
      Ralb
      Rattus norvegicus
      Hras
      Rattus norvegicus
      Eras
      Rattus norvegicus
      LOC108348138
      Rattus norvegicus
      Rem1
      Rattus norvegicus
      Rras2
      Rattus norvegicus
      LOC108348138
      Rattus norvegicus
      Eras
      Rattus norvegicus
      Hras
      Rattus norvegicus
      Gem
      Rattus norvegicus
      Rrad
      Rattus norvegicus
      Rras
      Rattus norvegicus
      Rem2
      Rattus norvegicus
      Ralb
      Rattus norvegicus
      Mras
      Rattus norvegicus
      Kras
      Rattus norvegicus
      Nras
      Rattus norvegicus
      Rala

      External links

      Saccharomyces Genome Database
      Search
      Ensembl
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      Entrez Gene
      View on Entrez Gene database (855625)
      Homologues
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      UniProt
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      Internet
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