Cell Senescence Entries for RRAD

Cell Types
Breast cancer, Gastric cancer, Prostate cancer
Cell Lines
DU145, LNCaP, MDA-MB-468, MKN74, PC-3, SNU-638, SNU-668
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Lee et al. (2010) A novel senescence-evasion mechanism involving Grap2 and Cyclin D interacting protein inactivation by Ras associated with diabetes in cancer cells under doxorubicin treatment. Cancer Res 70(11)4357-65 (PubMed)

RRAD Gene Information

HGNC symbol
RRAD 
Aliases
RAD; REM3 
Common name
RRAD, Ras related glycolysis inhibitor and calcium channel regulator 
Entrez Id
6236
Description

RRAD Ontologies

Gene Ontology
Process: GO:1901841; regulation of high voltage-gated calcium channel activity
GO:1901842; negative regulation of high voltage-gated calcium channel activity
GO:7264; small GTPase mediated signal transduction
Cellular component: GO:16020; membrane
GO:5886; plasma membrane
GO:5829; cytosol
Function: GO:166; nucleotide binding
GO:3924; GTPase activity
GO:5525; GTP binding
GO:5515; protein binding
GO:5516; calmodulin binding
GO:5246; calcium channel regulator activity
Show all GO terms

Homologs of RRAD in Model Organisms

Caenorhabditis elegans
Y52B11A.4
Danio rerio
rrad
Drosophila melanogaster
Rgk1
Drosophila melanogaster
Rgk3
Drosophila melanogaster
Rgk2
Drosophila melanogaster
CG42541
Mus musculus
Rrad
Rattus norvegicus
Rrad
Saccharomyces cerevisiae
RAS2
Saccharomyces cerevisiae
RAS1

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as RAS1
  • A homolog of this gene for Saccharomyces cerevisiae is present as RAS2

External links

OMIM
179503
Ensembl
ENSG00000166592
Entrez Gene
6236
UniGene
1027
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RRAD
GeneCards
RRAD