Cell Senescence Entries for NRAS
- Cell Types
- Foreskin melanocyte
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Mutation, Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Denoyelle et al. (2006) Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway. Nat Cell Biol 8(10)1053-63 (PubMed)
NRAS Gene Information
- HGNC symbol
- NRAS
- Aliases
- N-ras
- Common name
- NRAS proto-oncogene, GTPase
- Entrez Id
- 4893
- Description
- This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011].
NRAS Ontologies
- Gene Ontology
-
Process: GO:7165; signal transduction
GO:7265; Ras protein signal transduction
GO:1938; positive regulation of endothelial cell proliferation
GO:165; MAPK cascade
Cellular component: GO:16020; membrane
GO:5794; Golgi apparatus
GO:5886; plasma membrane
GO:139; Golgi membrane
GO:5789; endoplasmic reticulum membrane
GO:5829; cytosol
GO:70062; extracellular exosome
GO:70821; tertiary granule membrane
Function: GO:166; nucleotide binding
GO:16787; hydrolase activity
GO:3924; GTPase activity
GO:5525; GTP binding
GO:3925; G protein activity
GO:5515; protein binding
GO:44877; protein-containing complex binding
GO:19003; GDP binding
Homologs of NRAS in Model Organisms
- Caenorhabditis elegans
- let-60
- Danio rerio
- nras
- Drosophila melanogaster
- Ras85D
- Mus musculus
- Nras
- Rattus norvegicus
- Nras
- Saccharomyces cerevisiae
- RAS2
- Saccharomyces cerevisiae
- RAS1
In other databases
- GenAge model organism genes
- CellAge gene expression
- This gene is present as NRAS
External links
- OMIM
- 164790
- Ensembl
- ENSG00000213281
- Entrez Gene
- 4893
- UniGene
- 486502
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- NRAS
- GeneCards
- NRAS