Cell Senescence Entries for NRAS

Cell Types
Foreskin melanocyte
Cell Lines
Primary cell
Cancer Cell?
No
Method
Mutation, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Denoyelle et al. (2006) Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway. Nat Cell Biol 8(10)1053-63 (PubMed)

NRAS Gene Information

HGNC symbol
NRAS 
Aliases
N-ras 
Common name
NRAS proto-oncogene, GTPase 
Entrez Id
4893
Description
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011].

NRAS Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:7265; Ras protein signal transduction
GO:1938; positive regulation of endothelial cell proliferation
GO:165; MAPK cascade
Cellular component: GO:16020; membrane
GO:5794; Golgi apparatus
GO:5886; plasma membrane
GO:139; Golgi membrane
GO:5789; endoplasmic reticulum membrane
GO:5829; cytosol
GO:70062; extracellular exosome
GO:70821; tertiary granule membrane
Function: GO:166; nucleotide binding
GO:16787; hydrolase activity
GO:3924; GTPase activity
GO:5525; GTP binding
GO:3925; G protein activity
GO:5515; protein binding
GO:44877; protein-containing complex binding
GO:19003; GDP binding
Show all GO terms

Homologs of NRAS in Model Organisms

Caenorhabditis elegans
let-60
Danio rerio
nras
Drosophila melanogaster
Ras85D
Mus musculus
Nras
Rattus norvegicus
Nras
Saccharomyces cerevisiae
RAS2
Saccharomyces cerevisiae
RAS1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as let-60
  • A homolog of this gene for Saccharomyces cerevisiae is present as RAS1
  • A homolog of this gene for Saccharomyces cerevisiae is present as RAS2
CellAge gene expression
  • This gene is present as NRAS

External links

OMIM
164790
Ensembl
ENSG00000213281
Entrez Gene
4893
UniGene
486502
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NRAS
GeneCards
NRAS