LongevityMap Gene

Gene details

HGNC symbol: HRAS
Aliases: CTLO; HAMSV; HRAS1; RASH1; p21ras; C-H-RAS; H-RASIDX; C-BAS/HAS; C-HA-RAS1
Common name: HRas proto-oncogene, GTPase
Description: This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 11p15.5
UCSC Genome Browser: View 11p15.5 on the UCSC genome browser
OMIM: 190020
Ensembl: ENSG00000174775
UniProt/Swiss-Prot: RASH_HUMAN
Entrez Gene: 3265
UniGene: 37003
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: let-60
Danio rerio: hrasb
Danio rerio: hrasa
Drosophila melanogaster: Ras85D
Mus musculus: Hras
Rattus norvegicus: Hras
Rattus norvegicus: Hras
Saccharomyces cerevisiae: RAS2
Saccharomyces cerevisiae: RAS1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as let-60
A homolog of this gene for Saccharomyces cerevisiae is present as RAS1
A homolog of this gene for Saccharomyces cerevisiae is present as RAS2

GenAge human genes

This gene is present as HRAS

CellAge

This gene is present as HRAS

Studies (4)

Significant/Non-significant: 1/3

Study 1

Longevity Association

Population

American (Georgia and Louisiana populations from African and European origin)

Study Design

Haplotype analysis was performed in three candidate genes, and the haplotype combinations were tested for association with exceptional longevity in the Georgia Centenarian Study (n=650) and Louisiana Healthy Aging Study (n=869)

Conclusions

An HRAS1 haplotype enhanced the effect of an APOE haplotype on exceptional survival, and a LASS1 haplotype further augmented its magnitude. These results were replicated in a second population.

Indentifier

Reference

Study 2

Longevity Association

Non-significant

Population

Study Design

The chromosomal region 11p.15.5 was investigated in 1321 centenarians and 1140 younger subjects from European samples

Conclusions

No significant results were observed for genes previously associated with longevity: TH, IGF2, INS and HRAS1

Indentifier

Reference

Study 3

Longevity Association: Non-significant
Population: Italian (Southern)
Study Design: A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions: After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
Indentifier

Study 4

Longevity Association

Non-significant

Population

American (Georgia and Louisiana populations from African and European origin)

Study Design

Subjects were recruited and stratified according to their genetically inferred ethnic affiliation to account for population structure. Haplotype analysis was performed in three candidate genes, and the haplotype combinations were tested for association with exceptional longevity.

Conclusions

LASS1 and HRAS1 were not individually associated with longevity

Indentifier

Reference