LongevityMap Gene
Gene details
- HGNC symbol
- HRAS
- Aliases
- CTLO; HAMSV; HRAS1; RASH1; p21ras; C-H-RAS; H-RASIDX; C-BAS/HAS; C-HA-RAS1
- Common name
- HRas proto-oncogene, GTPase
- Description
- This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 11p15.5
- UCSC Genome Browser
- View 11p15.5 on the UCSC genome browser
- OMIM
- 190020
- Ensembl
- ENSG00000174775
- UniProt/Swiss-Prot
- RASH_HUMAN
- Entrez Gene
- 3265
- UniGene
- 37003
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- let-60
- Danio rerio
- hrasb
- Danio rerio
- hrasa
- Drosophila melanogaster
- Ras85D
- Mus musculus
- Hras
- Rattus norvegicus
- Hras
- Rattus norvegicus
- Hras
- Saccharomyces cerevisiae
- RAS2
- Saccharomyces cerevisiae
- RAS1
In other databases
- GenAge model organism genes
- GenAge human genes
- This gene is present as HRAS
- CellAge
- This gene is present as HRAS
Studies (4)
Significant/Non-significant: 1/3
Study 1
- Longevity Association
- Significant
- Population
- American (Georgia and Louisiana populations from African and European origin)
- Study Design
- Haplotype analysis was performed in three candidate genes, and the haplotype combinations were tested for association with exceptional longevity in the Georgia Centenarian Study (n=650) and Louisiana Healthy Aging Study (n=869)
- Conclusions
- An HRAS1 haplotype enhanced the effect of an APOE haplotype on exceptional survival, and a LASS1 haplotype further augmented its magnitude. These results were replicated in a second population.
- Indentifier
- HRAS
- Reference
Study 2
- Longevity Association
- Non-significant
- Population
- European
- Study Design
- The chromosomal region 11p.15.5 was investigated in 1321 centenarians and 1140 younger subjects from European samples
- Conclusions
- No significant results were observed for genes previously associated with longevity: TH, IGF2, INS and HRAS1
- Indentifier
- HRAS
- Reference
Study 3
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs12628
- Reference
Study 4
- Longevity Association
- Non-significant
- Population
- American (Georgia and Louisiana populations from African and European origin)
- Study Design
- Subjects were recruited and stratified according to their genetically inferred ethnic affiliation to account for population structure. Haplotype analysis was performed in three candidate genes, and the haplotype combinations were tested for association with exceptional longevity.
- Conclusions
- LASS1 and HRAS1 were not individually associated with longevity
- Indentifier
- HRAS
- Reference