Cell Senescence Entries for RRAS2

Cell Types
HUVEC
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Chen et al. (2019) 3' UTR lengthening as a novel mechanism in regulating cellular senescence. Genome Res 13(2)117-26 (PubMed)

RRAS2 Gene Information

HGNC symbol
RRAS2 
Aliases
TC21 
Common name
RAS related 2 
Entrez Id
22800
Description
This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010].

RRAS2 Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:7265; Ras protein signal transduction
GO:1649; osteoblast differentiation
GO:1901214; regulation of neuron death
GO:30335; positive regulation of cell migration
Cellular component: GO:16020; membrane
GO:5794; Golgi apparatus
GO:5886; plasma membrane
GO:5925; focal adhesion
GO:139; Golgi membrane
GO:70062; extracellular exosome
GO:5783; endoplasmic reticulum
Function: GO:166; nucleotide binding
GO:16787; hydrolase activity
GO:3924; GTPase activity
GO:5525; GTP binding
GO:5515; protein binding
GO:19003; GDP binding
Show all GO terms

Homologs of RRAS2 in Model Organisms

Caenorhabditis elegans
ras-1
Danio rerio
rras2
Drosophila melanogaster
Ras64B
Mus musculus
Rras2
Rattus norvegicus
Rras2
Saccharomyces cerevisiae
RAS2
Saccharomyces cerevisiae
RAS1

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as RAS1
  • A homolog of this gene for Saccharomyces cerevisiae is present as RAS2

External links

OMIM
600098
Ensembl
ENSG00000133818
Entrez Gene
22800
UniGene
712835
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RRAS2
GeneCards
RRAS2