LongevityMap Gene

Gene details

HGNC symbol: ADIPOQ
Aliases: ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1
Common name: adiponectin, C1Q and collagen domain containing
Description: This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]
Cytogenetic Location: 3q27.3
UCSC Genome Browser: View 3q27.3 on the UCSC genome browser
OMIM: 605441
Ensembl: ENSG00000181092
UniProt/Swiss-Prot: A8K660_HUMAN
Entrez Gene: 9370
UniGene: 80485
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: adipoqb
Mus musculus: Adipoq
Rattus norvegicus: Adipoq

Studies (6)

Significant/Non-significant: 3/3

Study 1

Longevity Association: Significant
Population: Jordanian
Study Design: SNPs rs266729 (-11377G/C), rs2241766 (+45T/G), and rs1501299 (+276 G/T) of adiponectin gene (ADIPQO) and rs7799039 (-2548C/A) SNP of leptin (LEP) gene were genotyped in 110 randomly selected elderly subjects (>85 years old) with mean age of 90.2 years, and 120 young control subjects (range from 20 to 50 years) with mean age of 32.0 years
Conclusions: No significant differences were detected in the genotype and allele frequencies of examined gene variants between the two groups (p > 0.05). However, when gender was considered, genotypes and alleles frequencies of rs1501299 SNP in ADIPOQ gene and rs7799039 in LEP gene were significantly associated with longevity in men (p < 0.02) but not in women (p > 0.05).
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Study 2

Longevity Association

Population

Study Design

The -11377C > G, -11391G > A, and -11426A > G promoter polymorphisms of ADIPOQ were studied for association with longevity in 148 centenarians and 414 young controls

Conclusions

A very rare AA genotype of the -11391G > A polymorphism was significantly more common in centenarians than in young controls

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Reference

Study 3

Longevity Association: Non-significant
Population: Ashkenazi Jewish
Study Design: Adiponectin levels and variants in the adiponectin gene (ADIPOQ) were studied in centenarians (n = 118), their offspring (n = 228), and unrelated participants <95 (n = 78)
Conclusions: Frequencies were not significantly different between probands and controls, though there was a suggestive difference in rs17300539 and APM1+2019 between male probands versus controls
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Study 4

Longevity Association: Non-significant
Population: American of Japanese origin
Study Design: Nested-case control study of 5 candidate longevity genes in 8006 Japanese American men from the Honolulu Heart Program and 3741 men part of the Honolulu Asia Aging Study
Conclusions: Genetic variants in ADIPOQ, FOXO1A, SIRT1 and COQ7 were not associated with longevity
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Study 5

Longevity Association: Significant
Population: Ashkenazi Jewish
Study Design: 205 centenarians (141 females, median age = 97 years and 64 males, median age = 97 years), their offspring (n = 145 total, 80 females, median age = 69 years and 65 males median age = 68 years), and 288 controls (167 females, median age = 74 years and 121 males, median age = 75 years) were examined for the association between genotype and longevity
Conclusions: A U-shape pattern of MTP CC genotype frequency with aging was observed. The CC was a buffered-deleterious genotype in the case group. In the control group without longevity genes, CC genotype included poorer survivorship.
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Study 6

Longevity Association: Non-significant
Population: Jordanian
Study Design: SNPs rs266729 (-11377G/C), rs2241766 (+45T/G), and rs1501299 (+276 G/T) of adiponectin gene (ADIPQO) and rs7799039 (-2548C/A) SNP of leptin (LEP) gene were genotyped in 110 randomly selected elderly subjects (>85 years old) with mean age of 90.2 years, and 120 young control subjects (range from 20 to 50 years) with mean age of 32.0 years
Conclusions: No significant differences were detected in the genotype and allele frequencies of examined gene variants between the two groups (p > 0.05). However, when gender was considered, genotypes and alleles frequencies of rs1501299 SNP in ADIPOQ gene and rs7799039 in LEP gene were significantly associated with longevity in men (p < 0.02) but not in women (p > 0.05).
Indentifier