LongevityMap variant group

Entry Details

Longevity Association: Non-significant
Population: Ashkenazi Jewish
Study Design: Adiponectin levels and variants in the adiponectin gene (ADIPOQ) were studied in centenarians (n = 118), their offspring (n = 228), and unrelated participants <95 (n = 78)
Conclusions: Frequencies were not significantly different between probands and controls, though there was a suggestive difference in rs17300539 and APM1+2019 between male probands versus controls

HGNC symbol: ADIPOQ
Aliases: ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1
Common name: adiponectin, C1Q and collagen domain containing
Description: This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]
Other longevity studies of this gene: 8
OMIM: 605441
Ensembl: ENSG00000181092
UniProt/Swiss-Prot: A8K660_HUMAN
Entrez Gene: 9370
UniGene: 80485
HapMap: View on HapMap