GenAge entry for BUB1B (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 197)

HGNC symbol
BUB1B 
Aliases
BUBR1; MAD3L; Bub1A; SSK1 
Common name
BUB1 mitotic checkpoint serine/threonine kinase B 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

BUB1B is a mitotic checkpoint that controls chromosome segregation and maintains genetic stability [1080]. BUB1B-null mice die at embryonic stages [1081], but accelerated ageing has been reported in mice with BUB1B insufficiency [1082]. Overexpression of BubR1, in mice, preserves genomic integrity, reduces tumorigenesis and extends average and maximum lifespan by 14% and 18%, respectively [3267]. In humans, mutations in the BUB1B gene have been associated with cancer [1733].

Cytogenetic information

Cytogenetic band
15q15
Location
40,161,009 bp to 40,221,136 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006468; protein phosphorylation
GO:0006915; apoptotic process
GO:0007062; sister chromatid cohesion
GO:0007067; mitotic nuclear division
GO:0007091; metaphase/anaphase transition of mitotic cell cycle
GO:0007093; mitotic cell cycle checkpoint
GO:0007094; mitotic spindle assembly checkpoint
GO:0008283; cell proliferation
GO:0031145; anaphase-promoting complex-dependent catabolic process
GO:0034501; protein localization to kinetochore
GO:0042787; protein ubiquitination involved in ubiquitin-dependent protein catabolic process
And 5 more GO terms
Cellular component: GO:0000776; kinetochore
GO:0000777; condensed chromosome kinetochore
GO:0000778; condensed nuclear chromosome kinetochore
GO:0000940; condensed chromosome outer kinetochore
GO:0005680; anaphase-promoting complex
GO:0005737; cytoplasm
GO:0005815; microtubule organizing center
GO:0005829; cytosol
GO:0048471; perinuclear region of cytoplasm
GO:0051233; spindle midzone
Function: GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
PARP1, BRCA2, MXI1, EEF2, SNCG, HDAC1, CCNA2, BUB1B, MDM2, SUMO1, BUB3, RAE1, TP73
STRING interaction network
Protein-Protein network diagram for BUB1B

Retrieve sequences for BUB1B

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
bub-1
Danio rerio
bub1bb
Drosophila melanogaster
BubR1
Drosophila melanogaster
Bub1
Mus musculus
Bub1b
Rattus norvegicus
Bub1b
Saccharomyces cerevisiae
MAD3
Saccharomyces cerevisiae
BUB1
Schizosaccharomyces pombe
bub1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Bub1b
CellAge
  • This gene is present as BUB1B
CellAge gene expression
  • This gene is present as BUB1B

Selected references

External links

EPD
ORF Accession
NM_001211
CDS Accession
NP_001202
OMIM
602860
HPRD
04176
Ensembl
BUB1B
UniProt/Swiss-Prot
BUB1B_HUMAN
GeneCards
BUB1B
Entrez Gene
701
GenAtlas
BUB1B
Internet
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