GenAge entry for BUB1B (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 197)
- HGNC symbol
- BUB1B
- Aliases
- BUBR1; MAD3L; Bub1A; SSK1
- Common name
- BUB1 mitotic checkpoint serine/threonine kinase B
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
BUB1B is a mitotic checkpoint that controls chromosome segregation and maintains genetic stability [1080]. BUB1B-null mice die at embryonic stages [1081], but accelerated ageing has been reported in mice with BUB1B insufficiency [1082]. Overexpression of BubR1, in mice, preserves genomic integrity, reduces tumorigenesis and extends average and maximum lifespan by 14% and 18%, respectively [3267]. In humans, mutations in the BUB1B gene have been associated with cancer [1733].
Cytogenetic information
- Cytogenetic band
- 15q15
- Location
- 40,161,009 bp to 40,221,136 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0006468; protein phosphorylation
GO:0006915; apoptotic process
GO:0007062; sister chromatid cohesion
GO:0007067; mitotic nuclear division
GO:0007091; metaphase/anaphase transition of mitotic cell cycle
GO:0007093; mitotic cell cycle checkpoint
GO:0007094; mitotic spindle assembly checkpoint
GO:0008283; cell proliferation
GO:0031145; anaphase-promoting complex-dependent catabolic process
GO:0034501; protein localization to kinetochore
GO:0042787; protein ubiquitination involved in ubiquitin-dependent protein catabolic process
And 5 more GO terms Cellular component: GO:0000776; kinetochore
GO:0000777; condensed chromosome kinetochore
GO:0000778; condensed nuclear chromosome kinetochore
GO:0000940; condensed chromosome outer kinetochore
GO:0005680; anaphase-promoting complex
GO:0005737; cytoplasm
GO:0005815; microtubule organizing center
GO:0005829; cytosol
GO:0048471; perinuclear region of cytoplasm
GO:0051233; spindle midzone
Function: GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- PARP1, BRCA2, MXI1, EEF2, SNCG, HDAC1, CCNA2, BUB1B, MDM2, SUMO1, BUB3, RAE1, TP73
- STRING interaction network
Retrieve sequences for BUB1B
Homologs in model organisms
- Caenorhabditis elegans
- bub-1
- Danio rerio
- bub1bb
- Drosophila melanogaster
- BubR1
- Drosophila melanogaster
- Bub1
- Mus musculus
- Bub1b
- Rattus norvegicus
- Bub1b
- Saccharomyces cerevisiae
- MAD3
- Saccharomyces cerevisiae
- BUB1
- Schizosaccharomyces pombe
- bub1
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Bub1b
- CellAge
- This gene is present as BUB1B
- CellAge gene expression
- This gene is present as BUB1B
Selected references
External links
- EPD
- ORF Accession
- NM_001211
- CDS Accession
- NP_001202
- OMIM
- 602860
- HPRD
- 04176
- Ensembl
- BUB1B
- UniProt/Swiss-Prot
- BUB1B_HUMAN
- GeneCards
- BUB1B
- Entrez Gene
- 701
- GenAtlas
- BUB1B
- Internet
- Search Google