GenAge entry for MXI1 (Homo sapiens)

Gene name (HAGRID: 90)

HGNC symbol: MXI1
Aliases: MXD2; MAD2; MXI; bHLHc11
Common name: MAX interactor 1, dimerization protein

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: MXI1 is an antagonist of MYC in that it competes with MYC for MAX [945]. Mice lacking MXI1 exhibit progressive, multisystem abnormalities and increased susceptibility to tumorigenesis. A role for MXI1 in murine ageing has thus been suggested [887]. Mutations in the human MXI1 gene have been linked to cancer [944]. Additional, more detailed, studies are necessary to determine whether MXI1 is related to human ageing.

Cytogenetic information

Cytogenetic band: 10q24-q25
Location: 110,226,004 bp to 110,287,365 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0008285; negative regulation of cell proliferation
GO:0042994; cytoplasmic sequestering of transcription factor
GO:1903507; negative regulation of nucleic acid-templated transcription

Cellular component:

GO:0005634; nucleus
GO:0005730; nucleolus
GO:0005737; cytoplasm

Function:

GO:0003677; DNA binding
GO:0003714; transcription corepressor activity
GO:0005515; protein binding
GO:0046983; protein dimerization activity

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: APP, BUB1B, MAX
STRING interaction network

Retrieve sequences for MXI1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: mdl-1
Danio rerio: mxi1
Mus musculus: Mxi1
Rattus norvegicus: Mxi1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as mdl-1

CellAge gene expression

This gene is present as MXI1