GenAge entry for HOXB7 (Homo sapiens)

Gene name (HAGRID: 213)

HGNC symbol: HOXB7
Aliases: HOX2; HOX2C
Common name: homeobox B7

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: HOXB7 is a member of the homeobox family, also called HOX, crucial in morphogenesis and development [1024]. The expression of many HOX genes, including HOXB7, declines with age, even prior to adulthood [1020]. An association of HOX genes with longevity has been proposed [1022], though there is no direct evidence linking HOXB7 to human ageing.

Cytogenetic information

Cytogenetic band: 17q21.3
Location: 48,607,233 bp to 48,611,021 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0007275; multicellular organism development
GO:0009952; anterior/posterior pattern specification
GO:0030099; myeloid cell differentiation
GO:0048704; embryonic skeletal system morphogenesis
GO:0090190; positive regulation of branching involved in ureteric bud morphogenesis

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm

Function:

GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0043565; sequence-specific DNA binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: PARP1, CREBBP, PRKDC, XRCC5, XRCC6, APP, NFKBIA
STRING interaction network

GenAge entry for HOXB7 (Homo sapiens)

Gene name (HAGRID: 213)

Potential relevance to the human ageing process

Cytogenetic information

Protein information

Protein interactions and network

Retrieve sequences for HOXB7

Homologs in model organisms

Selected references

External links