GenAge entry for XRCC6 (Homo sapiens)

Gene name (HAGRID: 117)

HGNC symbol
XRCC6 
Aliases
D22S731; D22S671; KU70; ML8; G22P1 
Common name
X-ray repair complementing defective repair in Chinese hamster cells 6 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

Like its counterpart XRCC5, XRCC6 is a helicase involved in DNA repair and chromatin remodelling [579]. Also called Ku70, XRCC6 has been linked to the telomeres [158], WRN [983], and other genes putatively regulating ageing. Mice with mutations in XRCC6 and XRCC5 exhibit signs of early ageing with low cancer levels, yet since XRCC5 mutants exhibit a similar phenotype the involvement of XRCC6 in the ageing phenotype is not clear in spite of some early signs of ageing in XRCC6 mutants [1906]. It is possible that XRCC6 is involved in ageing, though further results are necessary to determine whether it plays a role in human ageing.

Cytogenetic information

Cytogenetic band
22q13.2
Location
41,621,163 bp to 41,664,048 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000723; telomere maintenance
GO:0006266; DNA ligation
GO:0006303; double-strand break repair via nonhomologous end joining
GO:0006310; DNA recombination
GO:0006351; transcription, DNA-templated
GO:0007420; brain development
GO:0032481; positive regulation of type I interferon production
GO:0032508; DNA duplex unwinding
GO:0045892; negative regulation of transcription, DNA-templated
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
And 8 more GO terms
Cellular component: GO:0000783; nuclear telomere cap complex
GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005730; nucleolus
GO:0005829; cytosol
GO:0016020; membrane
GO:0043564; Ku70:Ku80 complex
GO:0070419; nonhomologous end joining complex
Function: GO:0003677; DNA binding
GO:0003684; damaged DNA binding
GO:0003690; double-stranded DNA binding
GO:0003691; double-stranded telomeric DNA binding
GO:0004003; ATP-dependent DNA helicase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0044212; transcription regulatory region DNA binding
GO:0044822; poly(A) RNA binding
GO:0044877; macromolecular complex binding
And 2 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, TERT, WRN, LMNA, MYC, PARP1, BRCA1, PIN1, CREBBP, RPA1, ABL1, PDPK1, CEBPA, EP300, HTT, EEF2, PRKDC, AR, XRCC5, PCNA, TERF2, XRCC6, BAX, EMD, HSF1, YWHAZ, SDHC, TFAP2A, MDM2, H2AFX, HOXB7, HOXC4, ESR1, CLU, SIRT6, PPARG, EPS8, SIRT7, TP53BP1, SIRT3
STRING interaction network
Protein-Protein network diagram for XRCC6

Retrieve sequences for XRCC6

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
cku-70
Danio rerio
xrcc6
Drosophila melanogaster
Irbp
Mus musculus
Xrcc6
Rattus norvegicus
Xrcc6
Saccharomyces cerevisiae
YKU70
Schizosaccharomyces pombe
pku70

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as cku-70
  • A homolog of this gene for Mus musculus is present as Xrcc6
  • A homolog of this gene for Saccharomyces cerevisiae is present as YKU70
LongevityMap
  • This gene is present as XRCC6

Selected references

External links

EPD
HS_G22P1
ORF Accession
NM_001469
CDS Accession
NP_001460
OMIM
152690
HPRD
01071
Ensembl
XRCC6
UniProt/Swiss-Prot
KU70_HUMAN
GeneCards
XRCC6
Entrez Gene
2547
GenAtlas
XRCC6
Internet
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