GenAge entry for NFKBIA (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 219)
- HGNC symbol
- NFKBIA
- Aliases
- IKBA; MAD-3; IkappaBalpha; NFKBI
- Common name
- nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
NFKBIA inhibits NF-kappa-B by forming a complex with it, and may be involved in inflammation, apoptosis, differentiation, and growth. Downregulation of NFKBIA with age appears to occur in the rat liver [871]. Transgenic mice expressing dominant-negative IkB, and exhibiting functional inhibition of NF-kB signaling in endothelial cells, were protected from age-related insulin resistance and vascular senescence and, displayed a prolonged lifespan. In addition, the mice had also decreased oxidative stress markers, increased muscle blood flow, enhanced active-phase locomotor activity, and aortic upregulation of mitochondrial sirtuin-related proteins [2115]. Whether NFKBIA plays a role in human ageing remains to be determined.
Cytogenetic information
- Cytogenetic band
- 14q13
- Location
- 35,401,510 bp to 35,404,754 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000060; protein import into nucleus, translocation
GO:0002223; stimulatory C-type lectin receptor signaling pathway
GO:0006915; apoptotic process
GO:0007253; cytoplasmic sequestering of NF-kappaB
GO:0010745; negative regulation of macrophage derived foam cell differentiation
GO:0010875; positive regulation of cholesterol efflux
GO:0010888; negative regulation of lipid storage
GO:0016032; viral process
GO:0031663; lipopolysaccharide-mediated signaling pathway
GO:0032088; negative regulation of NF-kappaB transcription factor activity
GO:0032270; positive regulation of cellular protein metabolic process
And 22 more GO terms Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0033256; I-kappaB/NF-kappaB complex
Function: GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0008139; nuclear localization sequence binding
GO:0019899; enzyme binding
GO:0031072; heat shock protein binding
GO:0031625; ubiquitin protein ligase binding
GO:0032403; protein complex binding
GO:0042802; identical protein binding
GO:0051059; NF-kappaB binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, NFKB2, HDAC3, NCOR1, PIN1, VCP, ABL1, NFKB1, UBE2I, TNF, PRKCA, RELA, HDAC1, MAPK14, PIK3R1, HDAC2, HOXB7, CLU, MTOR, NCOR2, IKBKB
- STRING interaction network
Retrieve sequences for NFKBIA
Homologs in model organisms
- Danio rerio
- nfkbiaa
- Danio rerio
- nfkbiab
- Drosophila melanogaster
- cact
- Mus musculus
- Nfkbia
- Rattus norvegicus
- Nfkbia
In other databases
- GenAge microarray genes
- This gene is present as NFKBIA
- GenDR gene expression
- A homolog of this gene for Mus musculus is present as Nfkbia
- CellAge
- This gene is present as NFKBIA