GenAge entry for TOP1 (Homo sapiens)

Gene name (HAGRID: 83)

HGNC symbol: TOP1
Aliases
Common name: topoisomerase (DNA) I

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: Topoisomerases regulate the topological states of DNA. Though no direct interaction has been reported, TOP1 has been indirectly linked to WRN [487]. TOP1 may also be important in the regulation of various brain functions and its activity is age-dependent [1625]. Because TOP1 has been associated with several DNA metabolism proteins thought to play a role in ageing, it is possible that TOP1 is itself involved in human ageing, though further studies are necessary to confirm this hypothesis.

Cytogenetic information

Cytogenetic band: 20q12-q13.
Location: 41,028,822 bp to 41,124,486 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:	GO:0006260; DNA replication GO:0006265; DNA topological change GO:0006338; chromatin remodeling GO:0007059; chromosome segregation GO:0007623; circadian rhythm GO:0012501; programmed cell death GO:0016032; viral process GO:0016310; phosphorylation GO:0016925; protein sumoylation GO:0032922; circadian regulation of gene expression GO:0040016; embryonic cleavage
	And 2 more GO terms

Cellular component:

GO:0000228; nuclear chromosome
GO:0000932; P-body
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0031298; replication fork protection complex
GO:0043204; perikaryon

Function:

GO:0001046; core promoter sequence-specific DNA binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003917; DNA topoisomerase type I activity
GO:0005515; protein binding
GO:0044822; poly(A) RNA binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, ATM, ERCC8, IL7R, MYC, PARP1, VCP, TOP2A, TOP2B, UBE2I, XRCC5, PCNA, APP, MDM2, ESR1, CDKN2A, BUB3, SIRT7
STRING interaction network

Retrieve sequences for TOP1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: top-1
Danio rerio: top1mt
Drosophila melanogaster: Top1
Mus musculus: Top1
Rattus norvegicus: Top1
Rattus norvegicus: Top1
Saccharomyces cerevisiae: TOP1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as top-1
A homolog of this gene for Saccharomyces cerevisiae is present as TOP1

CellAge

This gene is present as TOP1