GenAge entry for IL7R (Homo sapiens)
Gene name (HAGRID: 27)
- HGNC symbol
- IL7R
- Aliases
- CD127
- Common name
- interleukin 7 receptor
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
IL7R is involved in inflammation and immune response. Though a role in human ageing has not been demonstrated, it is possible that IL7R is related to age-related changes and pathologies, namely, at the level of the immune system [296].
Cytogenetic information
- Cytogenetic band
- 5p13
- Location
- 35,856,875 bp to 35,879,603 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000018; regulation of DNA recombination
GO:0000902; cell morphogenesis
GO:0001915; negative regulation of T cell mediated cytotoxicity
GO:0002377; immunoglobulin production
GO:0006955; immune response
GO:0007165; signal transduction
GO:0007166; cell surface receptor signaling pathway
GO:0008361; regulation of cell size
GO:0010628; positive regulation of gene expression
GO:0016049; cell growth
GO:0030217; T cell differentiation
And 6 more GO terms Cellular component: GO:0005576; extracellular region
GO:0005886; plasma membrane
GO:0009897; external side of plasma membrane
GO:0016021; integral component of membrane
Function: GO:0003823; antigen binding
GO:0004917; interleukin-7 receptor activity
GO:0005515; protein binding
Protein interactions and network
Retrieve sequences for IL7R
Homologs in model organisms
Selected references
External links
- EPD
- ORF Accession
- NM_002185
- CDS Accession
- NP_002176
- OMIM
- 146661
- HPRD
- 00893
- Ensembl
- IL7R
- UniProt/Swiss-Prot
- IL7RA_HUMAN
- GeneCards
- IL7R
- Entrez Gene
- 3575
- GenAtlas
- IL7R
- Internet
- Search Google