Saccharomyces cerevisiaeGenAge entry for TOP1 (Saccharomyces cerevisiae)

Gene information (ID: 1547)

Symbol
TOP1
Aliases
MAK1; MAK17
Name
TOPoisomerase
Organism
Saccharomyces cerevisiae (AnAge)

Potential relevance to longevity and/or ageing

Observations
Replicative lifespan decreased by 60% in the alpha strain
% change in avg or median lifespan
Replicative lifespan is 60% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Deletion
Longevity Category
Necessary for fitness
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as top-1
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as TOP1
    CellAge
    • A homolog of this gene for Homo sapiens is present as TOP1

    Homologs in other organisms

    Caenorhabditis elegans
    top-1
    Danio rerio
    top1mt
    Danio rerio
    top1mt
    Danio rerio
    top1l
    Danio rerio
    zgc:173742
    Danio rerio
    top1
    Drosophila melanogaster
    Top1
    Homo sapiens
    TOP1MT
    Homo sapiens
    TOP1
    Mus musculus
    Top1
    Mus musculus
    Top1mt
    Rattus norvegicus
    Top1mt
    Rattus norvegicus
    Top1
    Rattus norvegicus
    Top1
    Schizosaccharomyces pombe
    top1

    External links

    Saccharomyces Genome Database
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (854156)
    Homologues
    Search HomoloGene
    UniProt
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    Internet
    Search Google or Search Google Scholar