Baker's yeast (Saccharomyces cerevisiae) longevity, ageing, and life history

Classification (HAGRID: 04669)

Taxonomy: Kingdom: Fungi
    Phylum: Ascomycota
        Class: Saccharomycetes
            Order: Saccharomycetales
                Family: Saccharomycetaceae
                    Genus: Saccharomyces
Species: Saccharomyces cerevisiae
Common name: Baker's yeast
Synonyms: Candida robusta, Saccharomyces ellipsoideus

Lifespan, ageing, and relevant traits

Maximum longevity

0.04 years (captivity)

Source

Multiple references, please see bibliography below

Sample size

Large

Data quality

Acceptable

Observations

The budding yeast suffers from clonal or replicative senescence in which each mother cell can only divide a limited amount of times to produce daughter cells; the number of divisions by the mother cell is thus used to determine lifespan. The accumulation of extrachromosomal ribosomal DNA circles has been suggested as a possible causal mechanism of replicative senescence [0045]. It is also possible to measure chronological lifespan in yeast in terms of stationary phase survival; that is, the survival of individual cells in a non-dividing state. Longevity varies considerably between strains and various manipulations, including caloric restriction which in yeast consists of reducing the glucose level, increase lifespan [0981]. Caloric restriction replicative lifespan extension in yeast has been reported to be a non-cell autonomous process. Conditioned medium from caloric restriction treated cells transmits the longevity benefit of caloric restriction to moved mother cells, suggesting the process may benefit neighbouring cells, not only the individual cell [1209].

Several genes have been identified that regulate clonal senescence or chronological lifespan [0056], but because these two measurements are fundamentally different some genes have been shown to have opposite effects on them [0746].

Life history traits (averages)

: No information is available on life history. Please contact us if you wish to suggest or contribute data.

Metabolism

No information on metabolism is available.

Species in other databases

GenAge

Genes have been associated with ageing in this organism

GenDR

Genes have been associated with dietary restriction through manipulations in this organism

References

[1209] Mei and Brenner (2015), Calorie restriction-mediated replicative lifespan extension in yeast is non-cell autonomous (PubMed)
[0937] Unal et al. (2011), Gametogenesis eliminates age-induced cellular damage and resets life span in yeast (PubMed)
[0932] Kaeberlein (2010), Lessons on longevity from budding yeast (PubMed)
[0981] Wolf and Austad (2010), Introduction: Lifespans and Pathologies Present at Death in Laboratory Animals
[0936] Shcheprova et al. (2008), A mechanism for asymmetric segregation of age during yeast budding (PubMed)
[0460] Kaeberlein et al. (2007), Recent developments in yeast aging (PubMed)
[0746] Kennedy et al. (2005), The enigmatic role of Sir2 in aging (PubMed)
[0004] Fabrizio and Longo (2003), The chronological life span of Saccharomyces cerevisiae (PubMed)
[0337] Tissenbaum and Guarente (2002), Model organisms as a guide to mammalian aging (PubMed)
[0056] Kaeberlein et al. (2001), Using yeast to discover the fountain of youth (PubMed)
[0015] Jazwinski (2001), New clues to old yeast (PubMed)
[0053] Guarente and Kenyon (2000), Genetic pathways that regulate ageing in model organisms (PubMed)
[0012] Gershon and Gershon (2000), The budding yeast, Saccharomyces cerevisiae, as a model for aging research: a critical review (PubMed)
[0069] Gershon and Gershon (2000), Paradigms in aging research: a critical review and assessment (PubMed)
[0338] Sinclair (1999), Yeast aging research: recent advances and medical relevance (PubMed)
[0045] Sinclair and Guarente (1997), Extrachromosomal rDNA circles--a cause of aging in yeast (PubMed)
[0044] Lundblad and Szostak (1989), A mutant with a defect in telomere elongation leads to senescence in yeast (PubMed)

External Resources

Integrated Taxonomic Information System: ITIS 194157
Animal Diversity Web: ADW account (if available)
Encyclopaedia of Life: Search EOL
NCBI Taxonomy: Taxonomy ID 4932
Entrez: Search all databases
Ageing Literature: Search Google Scholar or Search PubMed
Images: Google Image search
Internet: Search Google