The PRKDC gene and its putative association with human ageing

Cell Senescence Entries for PRKDC

Cell Types: Lung cancer
Cell Lines: H460
Cancer Cell?: Yes
Method: Knockdown
Type of senescence: Stress-induced
Senescence Effect: Inhibits
Primary Reference: Azad et al. (2012) Inhibition of DNA-dependent protein kinase induces accelerated senescence in irradiated human cancer cells. Mol Cancer Res 9(12)1696-707 (PubMed)

PRKDC Gene Information

HGNC symbol: PRKDC
Aliases: DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1; HYRC; HYRC1; p350; p460; XRCC7
Common name: protein kinase, DNA-activated, catalytic subunit
Entrez Id: 5591
Description: This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010].

PRKDC Ontologies

Gene Ontology

Process:

GO:16310; phosphorylation
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:6303; double-strand break repair via nonhomologous end joining
GO:6310; DNA recombination
GO:2376; immune system process
GO:45087; innate immune response
GO:48511; rhythmic process
GO:6468; protein phosphorylation
GO:18105; peptidyl-serine phosphorylation
GO:1902036; regulation of hematopoietic stem cell differentiation
GO:42254; ribosome biogenesis
GO:6302; double-strand break repair
GO:2001034; positive regulation of double-strand break repair via nonhomologous end joining
GO:1933; negative regulation of protein phosphorylation
GO:8630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6464; cellular protein modification process
GO:45727; positive regulation of translation
GO:42752; regulation of circadian rhythm
GO:18107; peptidyl-threonine phosphorylation
GO:2218; activation of innate immune response
GO:32869; cellular response to insulin stimulus
GO:723; telomere maintenance
GO:45648; positive regulation of erythrocyte differentiation
GO:43066; negative regulation of apoptotic process
GO:45621; positive regulation of lymphocyte differentiation
GO:48660; regulation of smooth muscle cell proliferation
GO:34462; small-subunit processome assembly
GO:33152; immunoglobulin V(D)J recombination
GO:31571; mitotic G1 DNA damage checkpoint signaling
GO:460; maturation of 5.8S rRNA
GO:1756; somitogenesis
GO:2326; B cell lineage commitment
GO:2328; pro-B cell differentiation
GO:2360; T cell lineage commitment
GO:7420; brain development
GO:7507; heart development
GO:10212; response to ionizing radiation
GO:10332; response to gamma radiation
GO:16233; telomere capping
GO:30098; lymphocyte differentiation
GO:31648; protein destabilization
GO:33077; T cell differentiation in thymus
GO:33151; V(D)J recombination
GO:33153; T cell receptor V(D)J recombination
GO:35234; ectopic germ cell programmed cell death
GO:43065; positive regulation of apoptotic process
GO:50678; regulation of epithelial cell proliferation
GO:97681; double-strand break repair via alternative nonhomologous end joining
GO:1905221; positive regulation of platelet formation
GO:44238; primary metabolic process

Cellular component:

GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:16020; membrane
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5829; cytosol
GO:5667; transcription regulator complex
GO:32991; protein-containing complex
GO:32993; protein-DNA complex
GO:32040; small-subunit processome
GO:70418; DNA-dependent protein kinase complex
GO:70419; nonhomologous end joining complex
GO:5958; DNA-dependent protein kinase-DNA ligase 4 complex

Function:

GO:5515; protein binding
GO:3723; RNA binding
GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:3677; DNA binding
GO:19904; protein domain specific binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:4672; protein kinase activity
GO:34511; U3 snoRNA binding
GO:3690; double-stranded DNA binding
GO:4677; DNA-dependent protein kinase activity
GO:19899; enzyme binding

Hide GO terms

Homologs of PRKDC in Model Organisms

Caenorhabditis elegans: atl-1
Danio rerio: prkdc
Mus musculus: Prkdc
Rattus norvegicus: Prkdc
Saccharomyces cerevisiae: MEC1

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as MEC1

GenAge human genes

This gene is present as PRKDC

LongevityMap

This gene is present as PRKDC

Cell Senescence Entries for PRKDC

PRKDC Gene Information

PRKDC Ontologies

Homologs of PRKDC in Model Organisms

In other databases

External links