LongevityMap Gene
Gene details
- HGNC symbol
- PRKDC
- Aliases
- HYRC; p350; DNAPK; DNPK1; HYRC1; IMD26; XRCC7; DNA-PKcs
- Common name
- protein kinase, DNA-activated, catalytic polypeptide
- Description
- This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]
- Cytogenetic Location
- 8q11.21
- UCSC Genome Browser
- View 8q11.21 on the UCSC genome browser
- OMIM
- 600899
- Ensembl
- ENSG00000253729
- UniProt/Swiss-Prot
- PRKDC_HUMAN
- Entrez Gene
- 5591
- UniGene
- 491682
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- atl-1
- Danio rerio
- prkdc
- Mus musculus
- Prkdc
- Rattus norvegicus
- Prkdc
- Saccharomyces cerevisiae
- MEC1
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as MEC1
- GenAge human genes
- This gene is present as PRKDC
- CellAge
- This gene is present as PRKDC
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs10109984
- Reference