LongevityMap variant group
Entry Details
- Longevity Association
- Non-significant
- Population
- American of Japanese origin
- Study Design
- 81 tagSNPs that provided virtually complete coverage of key mTOR genes complex genes MTOR, RPTOR, and RICTOR, as well as RPS6KA1, were tested in 814 males (440 aged 95 years and older, 374 controls) for association with longevity and health span phenotypes.
- Conclusions
- No association was found between genotypes and longevity or aging-related biologic, clinical or functional phenoypes after mutiple test correction.
Variants (78)
- Gene summary:
- No gene (3)
- LOC400627 (2)
- MTOR (6)
- RICTOR (7)
- RPS6KA1 (2)
- RPTOR (58)
No gene
LOC400627
Gene details
- HGNC symbol
- LOC400627
- Aliases
- Common name
- uncharacterized LOC400627
- Description
- Other longevity studies of this gene
- 1
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 400627
- UniGene
- 591201
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
MTOR
Gene details
- HGNC symbol
- MTOR
- Aliases
- SKS; FRAP; FRAP1; FRAP2; RAFT1; RAPT1
- Common name
- mechanistic target of rapamycin
- Description
- The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]
- Other longevity studies of this gene
- 9
- OMIM
- 601231
- Ensembl
- ENSG00000198793
- UniProt/Swiss-Prot
- MTOR_HUMAN
- Entrez Gene
- 2475
- UniGene
- 338207
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- mtor
- Drosophila melanogaster
- Tor
- Mus musculus
- Mtor
- Rattus norvegicus
- Mtor
- Saccharomyces cerevisiae
- TOR1
- Schizosaccharomyces pombe
- tor2
In other databases
RICTOR
Gene details
- HGNC symbol
- RICTOR
- Aliases
- PIA; AVO3; hAVO3
- Common name
- RPTOR independent companion of MTOR complex 2
- Description
- RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
- Other longevity studies of this gene
- 7
- OMIM
- 609022
- Ensembl
- ENSG00000164327
- UniProt/Swiss-Prot
- RICTR_HUMAN
- Entrez Gene
- 253260
- UniGene
- 407926
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- rict-1
- Danio rerio
- rictorb
- Danio rerio
- rictora
- Drosophila melanogaster
- rictor
- Mus musculus
- Rictor
- Rattus norvegicus
- Rictor
- Saccharomyces cerevisiae
- TSC11
- Schizosaccharomyces pombe
- ste16
In other databases
RPS6KA1
Gene details
- HGNC symbol
- RPS6KA1
- Aliases
- RSK; HU-1; RSK1; p90Rsk; MAPKAPK1A
- Common name
- ribosomal protein S6 kinase A1
- Description
- This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 1
- OMIM
- 601684
- Ensembl
- ENSG00000117676
- UniProt/Swiss-Prot
- KS6A1_HUMAN
- Entrez Gene
- 6195
- UniGene
- 149957
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- rskn-1
- Danio rerio
- rps6ka1
- Drosophila melanogaster
- S6kII
- Mus musculus
- Rps6ka1
- Rattus norvegicus
- Rps6ka1
- Saccharomyces cerevisiae
- TPK3
In other databases
RPTOR
Gene details
- HGNC symbol
- RPTOR
- Aliases
- KOG1; Mip1
- Common name
- regulatory associated protein of MTOR complex 1
- Description
- This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
- Other longevity studies of this gene
- 63
- OMIM
- 607130
- Ensembl
- ENSG00000141564
- UniProt/Swiss-Prot
- Q6DKI0_HUMAN
- Entrez Gene
- 57521
- UniGene
- 133044
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- daf-15
- Danio rerio
- rptor
- Drosophila melanogaster
- raptor
- Mus musculus
- Rptor
- Rattus norvegicus
- Rptor
- Saccharomyces cerevisiae
- KOG1
- Schizosaccharomyces pombe
- mip1