Cell Senescence Entries for MTOR

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Knockout
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Liu et al. (2020) A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. Aging (Albany NY) 11(12)4011-4031 (PubMed)

MTOR Gene Information

HGNC symbol
MTOR 
Aliases
FLJ44809; FRAP; FRAP1; FRAP2; RAFT1; RAPT1 
Common name
mechanistic target of rapamycin kinase 
Entrez Id
2475
Description
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Aug 2020].

MTOR Ontologies

Gene Ontology
Process: GO:16310; phosphorylation
GO:80135; regulation of cellular response to stress
GO:6950; response to stress
GO:18105; peptidyl-serine phosphorylation
GO:2000112; regulation of cellular macromolecule biosynthetic process
GO:42221; response to chemical
GO:32270; positive regulation of cellular protein metabolic process
GO:48511; rhythmic process
GO:6468; protein phosphorylation
GO:32956; regulation of actin cytoskeleton organization
GO:10628; positive regulation of gene expression
And 83 more GO terms
Cellular component: GO:31931; TORC1 complex
GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:31410; cytoplasmic vesicle
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:43231; intracellular membrane-bounded organelle
GO:5739; mitochondrion
GO:5765; lysosomal membrane
And 12 more GO terms
Function: GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:44877; protein-containing complex binding
GO:5515; protein binding
GO:42802; identical protein binding
GO:51219; phosphoprotein binding
And 7 more GO terms
Show all GO terms

Homologs of MTOR in Model Organisms

Danio rerio
mtor
Drosophila melanogaster
Tor
Mus musculus
Mtor
Rattus norvegicus
Mtor
Saccharomyces cerevisiae
TOR1
Schizosaccharomyces pombe
tor2

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Tor
  • A homolog of this gene for Saccharomyces cerevisiae is present as TOR1
  • A homolog of this gene for Mus musculus is present as Mtor
GenAge human genes
  • This gene is present as MTOR
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as TOR1
LongevityMap
  • This gene is present as MTOR

External links

OMIM
601231
Ensembl
ENSG00000198793
Entrez Gene
2475
UniGene
338207
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MTOR
GeneCards
MTOR